Today’s physicians are dramatically different from their predecessors. Besides needing to know how to diagnose and treat biomedical illness, they must also be systems thinkers, able to discern how social, economic, environmental and technological forces factor into clinical decision-making. The Health Systems Science: Introduction to Quality Improvement and Patient Safety  helps medical students understand why the domain of health systems science is an essential component of their training and central to their long-term success as physicians. It also describes how health systems science complements the basic and clinical sciences and explains how integrating it into curricula can further medicine’s goal of improving public health.