UT Health San Antonio is the primary training site for health professionals serving the South Texas region. As a result of long-standing partnerships and productive relationships formed since its founding, UT Health San Antonio has grown to be a major education and research institution and is the chief catalyst for the leading sector of the San Antonio economy, the biosciences and health care industry. Designated as a Hispanic-Serving Institution by the US Department of Education, the Health Science Center is the largest comprehensive health sciences university in South Texas, and the only tier-one research institution in South Texas.

Long School of Medicine faculty are international leaders in behavioral health, neuroscience, imaging research, cancer, diabetes, healthy development and aging, and many other fields. Their affiliation with UT Health San Antonio other provides access to institutional core facilities, 13 UT Health San Antonio centers and institutes, funding programs, six clinical care partners, and several partner institutions (including the Texas Biomedical Research Institute and the Southwest Research Institute).