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Center for South Texas Programs, Conduct health services research with the goal of reducing and eliminating health disparities., Institute for Health Promotions Research, Studies causes and solutions of health issues facing Hispanics such as cancer, diabetes and chronic disease., ReACH Center, A collaboration of researchers and physicians to promote the health of South Texas residents, especially its majority Hispanic population, through comparative effectiveness research (the study of health care interventions to determine which work best for patients).
Over the course of the next five years, the goal is to build a solid foundation and position the Center to obtain national distinction. Under the auspices of the Institute for Integration of Medicine & Science (IIMS), the Center solicited the first round of pilot proposals this past spring. Out of ten proposals submitted in the inaugural year, five projects were selected to receive a total of…, Dr. Jean Chrisostome Bopassa’s, project focuses on, mitochondrial dysfunction, and subsequent respiratory chain deficits. The PD-related proteins parkin and PINK1 promote the destruction of damaged mitochondria, but the mechanism for this damage is poorly understood. By contrast, the protein mitofilin maintains mitochondrial structure and function, and mitofilin knockdown increases PD-like mitochondrial dysfunction and apoptosis. Dr. Bopassa’s team will develop a novel…, Dr. Brij Singh’s, laboratory examines the contribution of disrupted, calcium homeostasis, to PD pathology. Among other cellular functions, calcium is transported and stored in the endoplasmic reticulum (ER) where it is required for proper protein synthesis and folding. In all cells, calcium release from the ER opens ion channels that replenish ER calcium. In dopaminergic neurons, TRPC1 (transient receptor potential canonical 1) is the ion channel responsible for this function. As…, Dr. Amrita Kamat’s, team will study whether β2-adrenergic receptor agonists like, formoterol and albuterol, , currently approved for treating asthma, can be re-purposed as new cost-effective therapeutic options to delay onset and slow PD progression. This research intends to replicate epidemiologic evidence from a Norwegian cohort study that Dr. Kamat carried out on a larger and more diverse population from the Veterans Administration. In tandem with the pre-clinical study, the Kamat laboratory will…, Dr. Senlin Li’s, team will utilize glial cell-derived neurotropic factor (GDNF) for the neuroprotection of dopaminergic neurons. Dr. Li believes that previous clinical trials of brain stem injections failed to deliver adequate GDNF to the cellular targets. He proposes a cell-based delivery system whereby transplanted hematopoietic stem cells expressing GDNF generate macrophages/microglia that home to areas of…, Dr. Biju Chandu, will study inhibitors of the Nox family of NADPH oxidases, which comprise enzymatic complexes likely involved in the oxidative stress and neuroinflammation observed in PD . The team is using a transgenic mouse model of PD to evaluate the expression patterns of various catalytic subunits of NADPH oxidase in PD-related brain regions, and to further characterize the poorly understood relationship…
Rising costs for research and development coupled with a highly competitive funding landscape have prompted researchers to explore other pathways to accelerate biomedical research and improve patient outcomes. Josephine A. Taverna , M.D., assistant professor of medicine (hematology-oncology) noted that one of her top reasons for joining UT Health San Antonio was the institution’s reputation and…
The multi-day event will be held on the Greehey campus March 27-29, and will feature a keynote address, core lab tours, informational presentations, and roundtable discussions focused on best practices to operate institutional research cores and new software features. Core lab tours will be hosted by Kristin Cano, Ph.D ., Technical Director of the Nuclear Magnetic Resonance Core ; Exing Wang, Ph.…, "Agilent is excited to see a record number of registered participants coming from all over the globe this year. We attribute the higher registration response to a couple of reasons. First, San Antonio is an attractive destination for conferences, and second, strategically scheduling our conference to follow the day after a premier annual meeting being held downtown overlaps with our target…, "When approached last summer by the Agilent planning team, I viewed hosting the conference as an excellent opportunity to cast a national spotlight on the administrators and the expert technical support staff who manage our 8 institutional core labs,” stated Dr. Ramirez-Solis , “In turn, we will also learn from expert attendees which will allow us to grow as professionals in the dynamic landscape…
John Gebhard, PhD, assistant vice president, OTC, praised the team for pivoting to a successful virtual platform for this year’s President’s Translational and Entrepreneurial Research Fund (PTEF), which was coordinated by Meagan Rockne, technology commercialization assistant, and Lindsey Dostal, program coordinator. “Even though we were working remotely, our whole team really banded together for…, Investigator, Job Title, Project Title, Type of Technology, Sepehr Bahadorani, MD Specialitst, Opthamology Computer-aided analysis of full-field electroretinogram Medical Device John Calhoon, MD Professor and Chair, Cardiothoracic Surgery Safe IV Project Medical Device Daniel Chupp, PhD candidate Graduate Student, Integrated Biomedical Studies Novel humanized mouse platform supporting Natural Human antibody production Therapeutic Robert De Lorenzo, MD…
Equally important, these meetings allow us to hear from investigators and support staff about their experiences in conducting clinical research and barriers and gaps in research infrastructure. In addition to our UT Health San Antonio research community, Texas Biomedical Research Institute investigators will be able to participate remotely through live streaming. For those unable to attend the…, Takeaways from the Forum:, Use of HSC and University Health System electronic medical record information to identify potential participants is possible with appropriate IRB approval. Adoption of evidence-based practices available on the National Center for Advancing Translational Science (NCATS) Trial Innovation Network (TIN) website which can be implemented locally. The “ Find-A-Study" website hosted by the Office of the…