March 3, 2000
Volume XXXIII, No. 9

Damaged collagen may be linked to bone fractures

Dr. Agrawal

Researchers at the Health Science Center are suggesting something new in the study of bone fractures--that the amount of damaged collagen in a bone may be directly linked to the likelihood the bone will fracture. Their studies may provide new direction in research about a problem that causes an estimated 900,000 hospitalizations nationwide each year.

Bone is a natural composite composed primarily of calcium-based mineral and an organic material known as collagen. Collagen, a fibrous protein found in skin, tendon, bone and dentin, appears to be a key component that determines the ability of bone to withstand sudden impacts, the scientists report in the February issue of Clinical Orthopaedics and Related Research. The lead author is Dr. Xiaodu Wang, adjunct assistant professor at the Health Science Center and assistant professor of engineering at The University of Texas at San Antonio.

Experts long have thought that bone brittleness was determined mostly by the amount of mineral in bone, as measured in bone density. But the amount of intact collagen may be just as important in predicting fracture incidence related to age.

"Low bone mineral density has been considered to be a major cause of age-related bone fractures. In recent years, researchers have realized that reduced bone mass may not be the only factor in bone becoming brittle with age," said Dr. C. Mauli Agrawal, director of the Center for Clinical Bioengineering at the Health Science Center and senior author on the publication. "Researchers have found the same bone density in younger people and older people, yet the fracture rate is dramatically higher in the older group. Could it be we have been studying only half of the equation?"

A woman of 75 is seven times more likely to fracture a bone than a woman of 45, even if the women have the same bone density, according to scientific literature cited in the paper.

While calcium supplements, hormone replacement and other therapies seek to prevent bone mineral loss, no current therapy can address age-related damage to a person's bone collagen. "Although fractures are a significant problem in the elderly, the research on the role of collagen is still in its infancy and does not indicate any changes in therapies at the current time," Dr. Agrawal said. "It is our hope that in the future, someone will come up with collagen-targeted therapies."

Bone collagen is apparent only at the molecular level and cannot be seen by the naked eye. Scientists are attempting to see how collagen changes in bone might be prevented. About 6.8 million fractures occur each year in the United States, according to the American Academy of Orthopaedic Surgeons. Over the course of a lifetime, each person will experience two fractures on average, the academy estimates.

Dr. Agrawal, Dr. Wang and their colleagues studied bone from 33 baboons that died of natural causes at San Antonio's Southwest Foundation for Biomedical Research. The animals ranged in age from 5 to 26 years--from young adults to the very old. Fifteen were males and 18 were females, and gender was studied as a variable.

The Health Science Center team shipped the bone specimens to collaborating Dutch scientists, who performed a biochemical process to separate damaged collagen from intact collagen. "We looked at the amount of collagen that was damaged as a function of age," Dr. Agrawal said. The study showed a 15 percent increase in the amount of damaged collagen in the oldest baboons compared to the youngest, and a 40 percent corresponding decrease in bone toughness in the older group. No significant changes in mineral content were detected.

"We are trying to replicate these exciting results in human bone samples," Dr. Agrawal said. These samples were acquired from tissue banks and the Musculoskeletal Transplant Foundation.

Researchers define bone "toughness" in terms of the energy it takes to break the bone. Fractures usually occur at impact, when energy is delivered suddenly to a specific area of the skeleton.

The San Antonio researchers conducted such tests on the baboon bone specimens. "We found that the mineral primarily determines the strength and stiffness of bone, but the collagen determines how tough it is," Dr. Agrawal said, noting that the collagen is flexible and more likely to absorb energy.

"We tend to think of bone in terms of stiff ceramic-like structure," he added. "But bone is a mixture of mineral and collagen. The ability of bone to sustain a sudden blow could be related as much to the protein content of the bone as to the amount of bone mineral."

Rep. Bonilla honored with white coat, star of excellence

The Health Science Center's Development Board honored U.S. Rep. Henry Bonilla on Feb. 24 for his efforts in Congress that have resulted in additional federal funding for health-related projects in South Texas.

Rep. Bonilla understands the importance of research and the need for resources to put science into motion, said Dr. John P. Howe, III, president. The congressman serves on the powerful House Appropriations Committee, including its Subcommittee on Labor, Health and Human Services, and Education. Since his arrival in Congress, funding for the National Institutes of Health (NIH), the agency that funds most medical research in this country, has been increased by $7.6 billion. Of critical importance for South Texas, NIH-funded initiatives at the Health Science Center have increased from $37 million to $48 million during that time.

(L-R) U.S. Rep. Henry Bonilla; his wife, Deborah Knapp Bonilla; and Dr. John P. Howe, III, president, visit at the Plaza Club downtown.

Rep. Bonilla stepped in to save Area Health Education Centers (AHECs) such as the ones that serve San Antonio, Del Rio, Laredo and the Lower Rio Grande Valley. Hundreds of South Texas young people are in the health professions today because AHEC funding was allowed to continue, Dr. Howe said.

The congressman fought for other South Texas projects that might have died during the Conference Committee portion of the appropriations process, Dr. Howe said.

Rep. Bonilla, accompanied by his wife, Deborah Knapp Bonilla, received a Health Science Center white coat of appreciation. The white coat, presented annually to incoming medical students, symbolizes researchers' and clinicians' commitment to research, health education and patient care. It is symbolic of the excellence, dedication and professionalism that their chosen field requires of them.

Joci Straus, president of the Health Science Center Development Board, presented the congressman with an acrylic star memento from the Development Board for his leadership on behalf of the biosciences and health professions. Mrs. Bonilla received roses for her own volunteer activities, including narration of the video commemorating the Health Science Center's 25th anniversary.

Newly Granted

The following new and competitive renewal grants and awards were recorded in the Office of Grants Management for December 1999.

Community Dentistry

"Dental Oncology Education Program," Dr. Daniel Jones, Texas A&M Research Foundation, $21,407, 1 year.

Family Practice

"HIV Program Evaluation & Development for the Bureau of HIV & STD Prevention," Dr. Alfonso Holguin, Texas Department of Health, $579,000, 1 year.

Institute of Biotechnology

"Spore in Breast Cancer Project 5," Dr. Wen-Hwa Lee, Baylor College of Medicine, $235,519, 1 year.

"Postdoctoral Fellowship for Marni Brisson: Involvement of BRCA2 BRC Repeats in RAD51-Mediated DNA Repair," Dr. Wen-Hwa Lee, Susan G. Komen Breast Cancer Foundation, $102,816, 3 years.


"Efficacy of MK-0991 Against Resistant Candida Albicans Isolates Displaying Specific Mechanisms of Resistance," Dr. Jose Luis Lopez-Ribot, Merck & Co. Inc., $35,655, 2 years.

"Intergovernmental Personnel Agreement (IPA) for Debbie Munoz-Medellin," Dr. Geoffrey Weiss, Biomedical Research Foundation of South Texas, $19,163, 1 year.

"Inclusion Body Syosis Phase II Study of B-Interferon 1A," Dr. Carlayne Jackson, University of Rochester, $6,075, 1 year.

"Cloning of the Gene for Adipocyte Differentiating Factor (ADF) and Its Production by Recombinant Methodology," Dr. Robert Gregerman, Morrison Trust, $63,413, 1 year.

"IPA for Dr. Gabriel Fernandes," Dr. Gabriel Fernandes, Biomedical Research Foundation of South Texas, $13,519, 1 year.

"Impaired Cytoch.c Oxidase in Ischemia/Reperfusion Injury of the Heart: Role of 4-Hydroxynonenal," Dr. Juanjuan Chen, American Heart Association, $195,000, 2 years.


"Graduate Student Support for Azenth Barrera," Dr. Joel Baseman, Southwest Foundation for Biomedical Research (SFBR), $4,493, 1 year.

"Graduate Student Support for Lisa Lott," Dr. Joel Baseman, SFBR, $4,493, 1 year.

"Graduate Student Support for Ricardo Carrion," Dr. Joel Baseman, SFBR, $4,493, 1 year.

"Graduate Student Salary Support for Michael Prouty," Dr. Joel Baseman, SFBR, $20,160, 1 year.

"Graduate Student Support for Angela Archer," Dr. Joel Baseman, SFBR, $4,493, 1 year.


"The Role of Photo-Activated Melanosomes & Cellular Anti-Oxidant Defenses in the Response of RPE Cells to Laser Radiation," Dr. Randolph Glickman, Air Force Office of Scientific Research, $167,599, 1 year.

"Enhancing Teaching Services in the Low Vision Clinic & the Pediatric Eye Clinic," Dr. Wichard A.J. Van Heuven, Santa Rosa Hospital, $17,650, 1 year.


"Women's Health Laboratory," Dr. Philip Valente, Texas Department of Health, $9,975, 1 year.

Pediatric Dentistry

"Comprehensive Dental Care to Patients/Santa Rosa Children's Outpatient Dental Center," Dr. Huw Thomas, Santa Rosa, $83,980, 1 year.


"Medical Director of Asthma Education Center at Santa Rosa Children's Hospital (SRCH)," Dr. Pamela Wood, Santa Rosa, $38,066, 1 year.

"Part-Time Services of a Data Coordinator at SRCH," Dr. Anthony Infante, Santa Rosa, $4,493, 1 year.

"Services of Psychologist," Dr. Celia Kaye, Santa Rosa, $7,787, 1 year.

"Medical Director for the SANE Program at SRCH," Dr. Celia Kaye, Santa Rosa, $12,449, 1 year.

"Respiratory Care Medical Director," Dr. Celia Kaye, Santa Rosa, $15,000, 1 year.

"Dietitian to SRCH & Children's Clinic," Dr. Celia Kaye, Santa Rosa, $21,414, 1 year.

"Part-Time Services of a Pediatric Oncologist," Dr. Celia Kaye, Santa Rosa, $70,708, 1 year.

"Pediatric Intensive Care Unit at SRCH," Dr. Celia Kaye, Santa Rosa, $522,881, 1 year.

"Epstein-Barr Virus Genital Shedding in HIV-1 Infected Women," Dr. Hal Jenson, University of Southern California, $7,800, 4 months.


"Child Guidance Center Residency Agreement," Dr. Charles Bowden, Bexar County Community Guidance Center, $162,312, 1 year.

"National Hispanic Medical Association Mentorship Program," Dr. Martha Medrano, National Hispanic Medical Association, $74,079, 1 year.


"Membrane-Related Bioeffects & Protein Nitration After High Peak Power Pulsed & Ultra-Wide-Band Microwave Radiation Exposures," Dr. Martin Meltz, Air Force Office of Scientific Research, $199,968, 1 year.

"VA-Radiology Oncology Services," Dr. Stewart Reuter, Veterans Administration, $1,506,408, 3 years.

Rehabilitation Medicine

"Resident Program Agreement," Dr. Nicolas Walsh, Santa Rosa, $47,742, 1 year.

"SRCH Faculty Physicians Programs," Dr. Nicolas Walsh, Santa Rosa, $55,000, 1 year.

Student Services

"Pell Grant Program," Robert Lawson, U.S. Department of Education, $7,114, 1 year.


"Texas Organ Sharing Alliance Medical Director," Dr. William Washburn, Texas Organ Sharing Alliance, $14,000, 1 year.

"TGFB Receptor Gene Mutation in Human Cancer," Dr. Michael Brattain, Case Western Reserve University, $30,061, 1 year.

"IPA--U.S. Army Institute of Surgical Research," Dr. Basil Pruitt, U.S. Army, $13,286, 1 year.

Polling sites open for early voting

Early voting for the March 14 primary is under way and polling sites are open at various locations for voters around the county. Polls will be open from 8 a.m. to 8 p.m. Saturday, March 4; from noon to 6 p.m. Sunday, March 5; and from 8 a.m. to 8 p.m. March 6-10. The polling site at the Bexar County Justice Center is closed on weekends.
  • Bexar County Justice Center, 300 Dolorosa

  • Central Park Mall, 622 N.W. Loop 410

  • Claude Black Center, 2805 E. Commerce

  • Crossroads Mall, 4522 Fredericksburg Road

  • Dellcrest Shopping Center, 1800 S. W.W. White Road

  • Handy Andy Supermarket, 4010 W. Commerce

  • Handy Andy Supermarket, 2801 Nogalitos

  • Handy Andy Supermarket, 910 Bandera Road

  • Handy Andy Supermarket, 8353 Culebra Road

  • HEB Central Market, 4821 Broadway

  • HEB No. 1, 1955 Nacogdoches

  • HEB No. 8, 300 W. Olmos

  • HEB No. 11, 400 Valley Hi Drive

  • HEB No. 20, 2929 Thousand Oaks

  • HEB No. 21, 3323 S.E. Military Drive

  • HEB No. 25, 7951 Guilbeau Road

  • Ingram Park Mall, 6301 N.W. Loop 410

  • McCreless Mall, 4100 S. New Braunfels

  • Rolling Oaks Mall, 6909 N. Loop 1604 East

  • St. Philip's College (Southwest Campus), 800 Quintana Road

  • Somerset Conference Center, 19644 Somerset Road

  • South Park Mall, 2310 S.W. Military Drive

  • Universal City Hall, 2150 Universal City Blvd.

  • Wal-Mart, 910 S.E. Military Drive

  • Wal-Mart, U.S. 281 & Loop 1604 N.E.

  • Wal-Mart, 5555 DeZavala Road

  • Westlakes Mall, 1401 S.W. Loop 410

  • Windsor Park Mall, 7900 Interstate 35 North

  • Prestigious journal prints letter on domestic violence

    The Feb. 17 New England Journal of Medicine includes a letter to the editor co-authored by Dr. Joe Thornton, Department of Psychiatry at the Health Science Center; Dr. Margaret Brackley, Department of Chronic Nursing Care; and Evelyn Swenson-Britt, clinical nurse specialist with the University Health System.

    The letter was written in response to a Journal article on domestic violence. In that article, the authors advised against listing abuse as a diagnosis on a patient's medical records in order to protect the patient's privacy.

    In the letter, Dr. Thornton, who established the SAFE Family Project at University Hospital, wrote that "information in the medical record is critical in providing support for the patient in any legal proceedings and for public health efforts. Specifically, the physician (not the nurse or social worker) must include in the medical record a diagnosis of 'adult battering and other maltreatment' and identify the reported perpetrator by name and relationship to the victim as directly quoted from the victim."

    "We have to end the secrecy that still surrounds the issue of domestic violence," said Dr. Thornton. "We can help put an end to the abuse by educating all our patients about the issue and identifying the abusers. To stop the violence, we have to stop the perpetrators."

    Drs. Brackley and Thornton, along with their project director, Swenson-Britt, hold funding from the Health Education Training Centers Alliance of Texas and The San Antonio Area Foundation to improve health care response to domestic violence through training and systemic change.

    The group also has major funding ($1.6 million) from the U.S. Centers for Disease Control and Prevention to mount a "coordinated community response to prevent intimate partner violence" in San Antonio and Bexar County.


    Training Teachers

    Health Science Center faculty attended a professional development course titled "Effective Clinical Teaching." The two-day workshop was presented by the Division of Educational Research and Development (ERD). The course provided participants an opportunity to engage in hands-on practice of clinical teaching skills.

    Thompson chaired panel developing
    prostate cancer diagnosis guidelines

    Dr. Ian Thompson, head of the Division of Urology in the Department of Surgery, oversaw the development of a Best Practice Policy on prostate cancer diagnosis for the American Urology Association (AUA).

    The policy report was developed by a multidisciplinary panel of physicians and was released as an article in the February issue of the journal Oncology. Dr. Thompson chaired the panel that included physicians from medical disciplines such as urology, internal medicine, family practice, gerontology and radiation oncology.

    According to the report, a combination of prostate specific antigen (PSA) testing and digital rectal examinations is the best method for early detection of prostate cancer. Physicians are advised to consider a biopsy when a PSA test reading falls within a certain range, when the PSA level significantly increases from one test to another or when results from a digital examination are abnormal. The policy discusses the use of PSA testing to detect disease recurrence and as a guide in pre-treatment staging (determining whether the cancer has spread beyond the prostate gland).

    "PSA has not only been extremely helpful in identifying those at risk for prostate cancer early enough to successfully treat the disease, but it also has dramatically improved our ability to stage and follow the disease," said Dr. Thompson. "Because PSA is such an excellent indicator of the extent of the disease, this simple blood test has dramatically reduced the number of additional tests that are required--reducing the time and expense of the evaluation of patients with newly diagnosed prostate cancer."

    Dr. Thompson added that the PSA test is an important follow-up tool for physicians as well. "A man who has had surgery for prostate cancer should have a PSA level of zero," said Dr. Thompson. "The follow-up is a periodic blood test only. The blood test also is helpful to follow men after radiation treatment. A rising PSA after either of these two treatments generally indicates failure."

    The AUA report also cites a dramatic increase in prostate cancer detection between 1986 and 1991 as a result of the increased use of PSA testing. Prostate cancer is the second leading cause of cancer mortality in males, contributing to approximately 30,000 deaths each year, according to the AUA.

    "The policy deals with the most common cancer in U.S. men," said Dr. Thompson. "Although institutions such as the Health Science Center are investigating many new avenues to prevent prostate cancer and innovative new treatments to manage the disease itself, many feel that early detection and treatment are key to controlling the disease. With the advent of PSA, a blood test that is one of the most powerful screening tests for any cancer, we have not only witnessed a tremendous leap forward in early diagnosis, but have also seen the beginnings of a fall in the death rate from the disease."

    The Best Practice Policy report is designed to focus on issues, such as PSA testing, that lack data for evidence-based guidelines. The prostate detection policy is the first Best Practice Policy developed by the AUA. In March, the entire report will be available on the Internet at

    Pizza pies raise money for March of Dimes

    The Health Science Center Office of the Bursar will sell pizza from 11 a.m. to 1 p.m. every Friday in March at the third-floor snack machine area. Proceeds from the pizza sale will benefit the March of Dimes.

    Single-topping pizza is $1 per slice or $10 for a whole, large pizza. Whole pizzas may be pre-ordered, prepaid and delivered to offices on the main campus. These pizzas must be ordered by noon each Thursday. For more information or to order a pizza, call Lindsie or Barbara at ext. 7-2564 or 7-2556.



    Inaugural year under way for Department of Radiation Oncology

    The Health Science Center's newest addition, the Department of Radiation Oncology, has begun its inaugural year under the direction of department Chairman Dr. Terence Herman.

    Radiation oncology was a division of the Department of Radiology before becoming an official department in December. Dr. Herman said the change in status should result in more visibility for the department, benefit faculty recruitment, build a stronger residency program and provide more funding for research efforts.

    "This should allow us to flourish," said Dr. Herman. "We have been very successful even as a division and will continue to move forward now that we are a department."

    The new department consists of 35 members, including seven Ph.D. faculty, four M.D. attending physicians and six residents. The clinical portion of the department is located at the Grossman Cancer Center, part of the Cancer Therapy & Research Center (CTRC). Department clinical staff members are involved in various research projects, including determining which anti-cancer drugs and other agents can best be used in conjunction with radiation treatment. Researchers also are investigating new initiatives in treating brain tumors and are working on drugs, such as melatonin, that can protect against radiation damage to normal tissues. Another area of interest is ultra-precise radiation dose delivery using intensity-modulated radiation therapy.

    "The changeover from division to a stand-alone department has been a smooth one," said Dr. Herman. He credits the support he has been given by Dr. Stewart Reuter, chairman of the Department of Radiology; Dr. James Young, dean of the Medical School; and Dr. John P. Howe, III, president.

    In addition, Dr. Herman singled out the support of Dr. Charles Coltman, president and CEO of the CTRC. "All of these people were pivotal to the success of our radiation oncology effort," Dr. Herman said. "We will continue to make our high-quality radiation therapy the best in the country."


    Injury Prevention & Research Center opening celebration is March 6

    Health Science Center faculty and staff are invited to attend a reception to celebrate the opening of the South Texas Injury Prevention & Research Center (STIPRC) at 4 p.m. Monday, March 6, in the auditorium.

    In addition to the reception, an exhibit will highlight STIPRC injury prevention programs. The STIPRC provides a number of programs designed to reduce injury-related death and disability in South Texas through a combination of education, research and intervention.

    Low vision expo scheduled for March 18

    The Health Science Center is co-hosting a low vision expo from 9 a.m. to 4 p.m. Saturday, March 18, at the Allied Health/Research Building. The event will include free eye screenings and opportunities for hands-on experience with the latest in aids for low vision.

    Representatives will be on hand to answer questions on optical aids, the latest eye medications and resources available to caregivers. The event also will include demonstrations of mobility training, how to use a cane, instruction on serving as a sighted guide and daily living skills.

    The expo is co-sponsored by the San Antonio Low Vision Club, the Texas Commission for the Blind, the San Antonio Lighthouse, Prevent Blindness, and the South Texas Veterans Health Care System, Audie L. Murphy Division Eye Clinic. Admission is free.

    Miles for Smiles run/walk and health fair set for March 25 at the HSC pavilion

    The Health Science Center Dental School Miles for Smiles 5K run, 2K walk, kids run and health fair will be held Saturday, March 25, at the university pavilion near the track. Registration begins at 7 a.m. and the 5K run starts at 8 a.m. The 2K walk will follow at 8:15 a.m. and the Kids Run will start at 9:15 a.m. A health fair and awards ceremony will be held after the races.

    The event is designed to help educate and promote good oral health. The money raised will be returned to the community through dental programs, which include the school-based fluoride rinse program, preventive sealant program and dental care services for the underserved areas of San Antonio.

    Registration is $12 before March 10 and $15 on race day for adults. Registration for children 12 years old and under is $8. Each entrant will receive an official Miles for Smiles commemorative T-shirt and is eligible to win various door prizes. Cash prizes of up to $75 will be awarded for overall winners, and awards will be presented for the top three finishers in several age groups. For more information, call ext. 7-3752.

    Alzheimer's disease lecture scheduled

    Dr. David Espino, community geriatrician in the Department of Family Practice, will present "Successful Aging: The Ups and Downs of Alzheimer's Disease" at noon Thursday, March 23, in the University Hospital Lecture Hall. For more information or to register, call University Hospital's Learning Resources Department at 358-2355.


    HSC researcher receives 2000 Brodie Award

    Dr. Bettie Sue Siler Masters, professor of biochemistry, has been awarded the 2000 Bernard B. Brodie Award in Drug Metabolism from the American Society for Pharmacology and Experimental Therapeutics (ASPET).

    She received the award for the significant impact her research has made on the field of drug metabolism. The Brodie Award, established by SmithKline Beecham Corporation and given every other year by ASPET, honors the foundational contributions of Bernard B. Brodie in the field of drug metabolism and disposition.

    Dr. Masters will receive the award during the Joint Annual Meeting of ASPET, the American Society of Biochemistry and Molecular Biology, the Pharmacological Society of Canada and the French Pharmacological Society in Boston on June 4-8.

    Dr. Masters, who holds the Robert A. Welch Chair in Chemistry in the Department of Biochemistry, heads a laboratory team studying nitric oxide synthases, which are enzymes in the body that control production of nitric oxide.


    Border health symposium offered March 11-15

    The Health Science Center will co-sponsor a spring symposium, titled "Border Health: Making a Difference," March 11-15 at the Hyatt Regency Hotel-Riverwalk. The event is designed to bring together environmental and medical professionals, community and civic leaders, and regulatory agency representatives from both the United States and Mexico.

    Speakers will include U.S. Sen. Kay Bailey Hutchison, U.S. Rep. Ciro Rodriguez and Texas Sen. Judith Zaffirini.

    Participants will discuss the environmental health needs of the border community, conditions that may impact those communities and the role of environmental health in economic development, among other issues.

    Additional symposium sponsors include the International Consortium for the Environment; the city of San Antonio; the Institute for Environment, Safety and Occupational Risk Analysis (IERA) at Brooks Air Force Base; the National Institute of Environmental Health Sciences at the National Institutes of Health; the U.S. Environmental Protection Agency; and the Texas Tech School of Medicine.

    For more information, contact Eric Stephens at IERA at 536-2003 or visit the informational Web site at

    Grant application workshop scheduled for April

    The Division of Educational Research and Development will conduct a course on writing grant applications from 9 a.m. to 4 p.m. April 20-21 in the School of Nursing auditorium.

    The hands-on workshop is designed to help faculty write clear, compelling and convincing grant applications. Participants will critique previously submitted National Institutes of Health grant applications and discuss strategies to avoid red flags. The program also will include exercises in writing in a fashion that is reviewer-friendly. Participants will receive a detailed manual summarizing writing strategies and a comprehensive list to guide development and editing of applications. Health Science Center faculty will not be charged to attend. For more information or to register, contact Gloria Nuckols at ext. 7-2282 or by e-mail at



    March 6 - 12


    8:00 a.m. Rehab Medicine Lecture Series "Therapeutic Exercise for Spinal Cord Injury," Drs. Robert Jensen & Mark Fredrickson (UH: Reeves Rehab Center 3rd-floor classroom)


    6:30 a.m. Podiatry Grand Rounds "Rear Foot Arthritis," Dr. Anthony Decuir (MED: 209L)

    8:00 a.m. Rehab Medicine Lecture Series "Contractures & Flexibility," Drs. Travis Hird & Mark Fredrickson (UH: Reeves Rehab Center 3rd-floor classroom)

    11:00 a.m. TNT "Blood Banking: Therapeutic Apheresis: Pathophysiology & Treatment Effects," Dr. Daniel Smith, Brooke Army Medical Center (call ext. 7-2700 for information)

    Noon TNT "Clinical Chemistry & Toxicology: Case Studies in Herbal Medicine Toxicity," Dr. George Kudolo (call ext. 7-2700 for information)

    Noon Medicine Research Conf. "Dendritic Cells & the Control of Immunity," Dr. Ralph Steinman, Rockefeller University (MED: 209L)

    1:15 p.m. Psychiatry Grand Rounds "Are Two Antidepressant Mechanisms Better Than One? Exploiting the Synergy Between Serotonin & Norepinephrine," Dr. Stephen Stahl, University of California, San Diego, School of Medicine (MED: 409L)

    4:00 p.m. Cardiovascular Pathobiology Research Conf. "Vascular Disease in Knockout Mice," Dr. Robert Reddick (MED: 331.5B)


    6:30 a.m. Podiatry Case Conf. (MED: 309L)

    7:00 a.m. Vascular Surgery Grand Rounds, Dr. Mellick Sykes (MED: 209L)

    8:00 a.m. Medical Grand Rounds "Diagnosis, Classification & Treatment of von Willebrand Disease," Dr. J. Evan Sadler, Washington University School of Medicine (MED: 409L)

    9:00 a.m. Surgery Trauma M&M Conf., Dr. Ronald Stewart (MED: 309L)

    10:00 a.m. TNT "Environmental Services: How to Fight Absenteeism," John Coleman, Texas School for the Blind & Visually Impaired (call ext. 7-2700 for information)

    10:00 a.m. TNT "Laboratory Management: Developing Successful Strategies for Meeting CAP Regulations," Dr. Ronald Laessig, University of Wisconsin (call ext. 7-2700 for information)

    Noon Pharmacology Seminar Series "Genetic Mapping Studies of Bipolar Disorder & Schizophrenia in a Population Isolate," Dr. Michael Escamilla (MED: 444B)


    7:30 a.m. Thoracic Surgery Resident Teaching Conf. (VA: 4th-floor CT Library A404 )

    7:30 a.m. Obstetrics & Gynecology Grand Rounds "Changing High-Risk Sexual Behavior: A Randomized Controlled Trial," Dr. Rochelle Shain (MED: 309L)

    11:00 a.m. TNT "Radiology: Quality Control for an Electronic Imaging Department," Jonathan Tucker, Brooke Army Medical Center (call ext. 7-2700 for information)

    Noon Pulmonary, Thoracic & Oncology Conf. (MED: 309L)

    Noon Microbiology Department Seminar Series "Cellular & Viral Factors in Alphaherpesvirus Entry," Dr. Robert Geraghty, Northwestern University, Chicago (MED: 444B)

    12:30 p.m. TNT "Pain Management: Cancer Pain Mini-Lectures: Options for Hospice & Occupational Therapy," Bonita Howard & Alison Beck (call ext. 7-2700 for information)

    3:00 p.m. Surgery Tumor Conference, Dr. Anatolio Cruz (MED: 209L)

    4:00 p.m. Molecular Medicine Seminar Series "DNA Repair: From Protein Structures to Gene Knockout Mice," Dr. Tomas Lindahl, Imperial Cancer Research Fund, United Kingdom (IBT: 3.002)

    4:30 p.m. Citywide Thoracic Grand Rounds "Case Presentation," Dr. A. Joseph Atiya (MED: 309L)


    7:30 a.m. Pediatric Grand Rounds "Evaluation of Mental Retardation in a Primary Care Setting," Dr. Chris Johnson (MED: 409L)

    8:00 a.m. Rehab Medicine Lecture Series "Acupuncture: A Review of Journal Articles," Drs. Jim Fernandez & Mark Fredrickson (UH: Reeves Rehab Center 3rd-floor classroom)

    8:30 a.m. Cardiovascular Research Conf. "Differential Effects of Calorie Restriction & Gender on Cardiac Baroreflex Sensitivity, Sympathetic Tone & Cardiac Ischemia-Reperfusion Damage in Rats," Dr. Irene Chapa (MED: 3.078V)


    7:15 a.m. Surgical Physiology Conf., Dr. Kenneth Sirinek (MED: 209L)

    9:00 a.m. General Surgery Grand Rounds, Dr. Wayne Schwesinger (MED: 209L)

    Index of Issues

    THE NEWS is published Fridays by the Office of Public Affairs for faculty and staff of The University of Texas Health Science Center at San Antonio.

    Vice President for University Relations.....Judy Petty Wolf
    Executive Director of Development & Public Affairs.....Dr. Charles Rodriguez
    News & Information Services Manager.....Will Sansom
    Editor.....Heather Feldman
    Writers.....Myong Covert, Catherine Duncan, Jennifer Lorenzo
    Photographers.....Jeff Anderson, Lee Bennack, Lester Rosebrock
    Designer.....Kris Doyle
    Web Editor.....Joanne Shaw
    Production.....Printing Services

    Office of Public Affairs, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900 (Mail Code 7768)
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