Microbiology, Immunology & Molecular Genetics Graduate Student
BSc. Microbiology, University of Pune, India
MSc. Virology, National Institute of Virology, India
Ebola virus (EBOV) causes a severe hemorrhagic disease in humans and nonhuman primates. It is highly pathogenic, with case fatality rates of up to 90%. There are currently no FDA approved vaccines or specific antiviral therapy. The recent EBOV outbreak in West Africa with around 28,000 cases and 11,000 deaths has highlighted the unpredictability of the geographic range of the virus. Antivirals may prove especially useful for such outbreaks since these are sporadic and it is difficult to predict populations at risk. Vascular leakage and barrier disruption are well known symptoms of infection. Though cytokines are thought to be involved, the effect of filovirus replication on cell adhesion signaling pathways is largely uncharacterized. Determining this role will have important implications for understanding viral pathogenesis.
Additionally, reports have indicated that Ebola infection induces an epithelial to mesenchymal transition (EMT)-like state in infected cells; which is known to infect cell adhesion. However the mechanism of induction has not yet been fully elucidated. My project in the Patterson lab is aimed at studying the effect of Ebola virus infection on host pathways affecting cell adhesion. Presently, I am examining early transcriptional changes in key genes related to the regulation of cell adhesion, as well as changes in protein levels after infection. Our goal is to identify important players of this pathway, which may aid in the development of better therapeutic interventions to manage thehemorrhagic manifestations of the disease.
Posters and Presentations
Manasi Tamhankar, Young-Tae Ro, Jean L. Patterson Effect of Filovirus Infection on Cell Adhesion 2015 ASM Biodefense and Emerging Diseases Research Meeting
Manasi Tamhankar, Young-Tae Ro, Jean L. Patterson. Cell-type specific regulation of adherens junction pathways in response to filovirus infection. 16th Negative Strand Virus Meeting, Siena, Italy
Manasi Tamhankar, Young-Tae Ro, Jean L. Patterson Effect of Filovirus Infection on Cell Adhesion 3rd Annual Vaccine Development Center of San Antonio Conference, San Antonio, Texas.