Microbiology, Immunology & Molecular Genetics | Faculty | Yan Xiang, Ph.D.

 

Microbiology, Immunology & Molecular Genetics Faculty

  Research | Publications | Lab Members


Yan Xiang, Ph.D.
Associate Professor

Microbiology, Immunology & Molecular Genetics
University of Texas Health Science Center San Antonio

4.031V - MED
Tel: (210) 567-0884
Fax: (210) 567-6612
Email: xiangy@uthscsa.edu

 

Personal Statement

Dr. Xiang worked on immune evasion mechanisms of poxviruses and discovered poxvirus interleukin-18 binding protein. Dr. Xiang has continued working on poxvirus immune evasion mechanism since the faculty of Dr. Xiang's current institute.

Education

Ph.D., Virology/Biochemisty at Case Western Reserve University, Cleveland, Ohio

Research

Keywords: Poxvirus

Research interests:
The primary interest of our laboratory is host-pathogen interactions, with poxviruses as our model systems.

Variola virus and molluscum contagiosum virus (MCV) are the only two members of poxvirus family that exclusively infect humans and cause human diseases. Variola virus is the causative agent of smallpox. A closely related poxvirus, vaccinia virus, serves as the vaccine for smallpox. However, the vaccination causes a relatively high level of immunization complications. MCV is still prevalent throughout the world. Unlike smallpox virus, MCV causes small, benign skin lesions in children and young adults and a more extensive disease only when there is a concurrent immunodeficiency such as AIDS. We are trying to understand the molecular mechanisms of poxviral pathogenesis by uncovering the functions of various poxviruses virulence factors.

Some of the poxviral virulent factors are soluble or membrane-bound proteins that directly modulate the host immune response. The discovery and characterization of these proteins provide insights into the mechanisms of viral pathogenesis as well as the functions of the host immune system. A new strategy of immune modulation was recently revealed by the discovery of a soluble interleukin-18 binding protein (IL-18BP) in poxviruses and their mammalian hosts. Interleukin-18 (IL-18) is a proinflammatory cytokine that can enhance both the innate and acquired immunity. IL-18 protects against microbial infection and tumors in murine models. Excessive IL-18 activities, however, are associated with many autoimmune and inflammatory diseases. The poxvirus and host IL-18BPs can bind to IL-18 with high affinities and inhibit IL-18 mediated IFN-gamma induction. Therefore, IL-18, IL-18BP and their mimetics are all potentially important therapeutic agents. We are continuing our studies on IL-18BP and are getting a detailed understanding of the specific interactions between IL-18 and its binding partners by using a combination of methods including sequence comparison, structural modeling, mutagenesis and quantitative molecular interaction.
 

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Awards and Accomplishments

1999 ASBMB/PABMB Graduate/Postdoctoral Travel Award
2001 Honorable Mention Recipient of Norman P. Salzman Memorial in Virology, Foundation for NIH
2002 Staff Recognition Award of NIAID/NIH

 

Publications

Complete List of Publications


 

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Updated 05.24.2016