Microbiology, Immunology & Molecular Genetics Faculty
Peter H. Dube, Ph.D.
Dr. Dube has studied Yersinia pathogenesis for the last 15 years and he has developed a variety of unique tools to study interaction of Yersinia with intestinal epithelial cells in vitro and in vivo. Dr. Dube has been continuously grant funded in the area of Yersinia pathogenesis and host immune responses for more than 15 years during this time he has served on numerous governmental advisory boards in the ares of mucosal immunology and infectious disease. Much of his work has evaluated host responses to Yersinia infection and regulation of gut inflammation and inflammation-associated sequellae induced after infection. Specifically, the Dube lab has elucidated the role of virulence factors produced by Yersinia in the modulation of signaling by IL-1 family members. He brings extensive research experience in immunology, bacterial pathogenesis, and host-immune responses to this project. The current application is an extension of novel findings recently reported by the Dube lab describing the mechanism of IL-18 expression in intestinal epithelial cells following Yersinia infection. Dr. Dube's laboratory was the first to elucidate the mechanisms of integrin-mediated inflammasome activation in intestinal epithelial cells (Thinwa et al. 2014 J. Immunol.). These studies showed that a bacterial protein called invasin was capable of providing the first signal for NLRP3-dependent IL-18-mediated protective responses. The current application exploits and applies these findings and the novel reagents developed by the Dube lab to the treatment and prevention of inflammatory bowel disease and colorectal cancer. Dr. Dube has made significant efforts to improve the training environment for graduate students and fellows over the last 7 years. He has lead the Microbiology, Immunology & Molecular Genetics training track at UTHSCSA and has been instrumental in the last two redesigns of the graduate school curricula. Part of his efforts have been to enhance exposure of students to learning approaches to graduate education.
Ph.D., Biochemistry at the State University of New York at Stony Brook
Keywords: Yersinia; Intestinal Epithelial Cells
Infectious diseases remain the number one killer of people worldwide and the recent emergence and re-emergence of serious human pathogens suggest that this trend will continue. Often the morbidity and mortality associated with infectious diseases can be directly linked to inflammation. Even with the great advances in immunology over the last twenty years, the pathogenesis of most infectious diseases remains poorly understood. This creates a significant problem in human health as many pathogens are now becoming resistant to current therapeutics.
The research in the laboratory focuses on the immuno-biology of infectious disease. Their interests are in innate and adaptive immunity, inflammation, and pathology due to inflammation. Their main goal is to understand how bacterial pathogens interact with mucosal surfaces of the host to cause disease. Understanding the cross talk between pathogens and the host is the key to unlocking the molecular mechanisms of disease and ultimately therapeutic intervention. To accomplish this goal, they study three pathogens Yersinia enterocolitica, Yersinia pestis, and Mycoplasma pneumoniae and their interactions with the gut and the lung respectively.
Their work directly examines the molecular mechanisms underlying a number of serious human diseases including food borne infections, pneumonia, allergy, and asthma. They take a multi-disciplinary approach to solving complex problems integrating techniques in animal modeling, molecular genetics, molecular and cellular immunology, biochemistry, and cell biology.
Much of the work in the lab investigates the roles of various cytokines and chemokines in the pathogenesis of disease. How these important signaling molecules are regulated during infection and the role of virulence factors in the modulation of cytokine responses leading to pathology is central to their understanding of disease. Recently they have begun to explore the the generation of allergic inflammation in response to infection.
Awards and Accomplishments
|2004||ERC New Faculty Award UTHSCSA "Host Responses to Yersinia Pestis"|
|2003||Howard Hughes Medical Institute Young Investigator Award|
|2000||Keck Postdoctoral Fellowship Award, Washington University School of Medicine|
- American Society For Microbiology
- American Association of Immunologists
- Editorial board member for Infection and Immunity
- Frontiers in Cellular Microbiology
Evseev AI, Semenov I, Archer CR, Medina JL, Dube PH, Shapiro MS and Brenner R (2013) Functional effects of KCNQ K+ channels in airway smooth muscle. Front. Physiol. 4:277. doi: 10.3389/fphys.2013.00277
- Medina, J.L., Coalson, J.J., Brooks, E.G., Winter, V.T., Chaparro, A., Principe, M.,Kannan, T.R., Baseman, J.B., and Peter H. Dube. 2012. Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation. Am J Respir Cell Mol Biol Jun;46(6):815-22 PMID: 22281984
- Bose, R., Thinwa, J., Chaparro, A., Zhong, Y., Zhong., G, Bose, S., and Dube, P.H., 2011. MAPkinase-dependent IL-1alpha intracrine signaling is modulated by YopP during Y. enterocolitica infection. Infect and Immun. Jan;80(1):289-97 PMID: 22083707
- Embry, A. E., Meng, X, Cantwell, A.M., Dube, P.H.,* and Yan Xiang.,* 2011. Enhancement of Immune Response to an Antigen Delivered by Vaccinia Virus by Displaying the Antigen on the Surface of Intracellular Mature Virion. Vaccine Jul 26;29(33):5331-9* corresponding authors PMID: 21664218
- Cantwell, A. M., Bubeck, S., and Dube, P.H., 2010. YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia. BMC Immunology. 11:29 PMID: 20565713
- Zhong, Y., Cantwell, A.M., and Dube, P.H. 2010. Transforming growth factor-beta and CD-25 is important for controlling systemic dissemination following Yersinia enterocolitica infection. Infect and Immun. 78:3716-3725 PMID: 20584975
- Hardy, R.D., Coalson,J.J., Peters, J.,Chapparo, A., Cantwell, A.M., Kannan, T.R., Baseman, J.B., and Dube, P.H. 2009. Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin. Plos one. 4:e7562. PMID: 19859545
- Dube, P. 2009 Interaction of Yersinia with the gut: mechanisms of pathogenesis and immune evasion.
- Curr. Top. Microbiol. Immunol. 337:61-91 PMID: 19812980
- Sabbah, A., Chang, T.H., Harnack, R., Frolich, V.C., Tominaga, K., Dube, P.H., Berton, M.T., Xiang, Y., and Bose, S. 2009. Activation of innate immune antiviral response by NOD2. Nat. Immunol. 10:1073- 1080. PMID: 19701189
- Xiaoyun Zhang, Gao, L., Lei L., Zhong, Y., Dube, P., Berton, M., Arulanandam, B., Zhang, J., and Zhong, G. 2009. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol. 183:1291-1300 PMID: 19542374