Microbiology, Immunology & Molecular Genetics Adjunct Faculty
Bernard P. Arulanandam, Ph.D., M.B.A.
Dr. Arulanandam is a cellular immunologist and has an established research program (< 15 years) focused on elucidating host-microbial interactions and cellular and molecular mechanisms involved in the induction of immune responses against infectious diseases. Dr. Arulanandam's research program has made significant contributions to the understanding of host-microbe interactions and identifying approaches to induce optimal mocosal protection and immunity. Administratively, he currently serves as the Assistant Vice President for Research and the Director of the South Texas Center for Emerging Infectious Diseases (STCEID), the Center for Infection Genomics (CEIG), and Co-Scientific Director of the San Antonio Vaccine Development Center. Within the last 10 years, Dr. Arulanandam has served as a mentor to 5 Ph.D. students. Dr. Arulanandam has extensively trained and mentored undergraduates and graduate students, who have gone on to successful professional programs and independent careers. Together, he has a proven track record of leadership, funding, publication history and fiscal/administrative management of a research program.
Ph.D., Microbiology & Immunology at the Medical College of Ohio (University of Toledo)
Keywords: Cellular Immunology; Mucosal Defenses; Respiratory Defenses
Mucosal surfaces form the major interface between the host and the environment, and constitute the first line of defense against pathogens. The mammalian mucosal immune system has evolved into an intricate network of tissues, lymphoid and mucus membrane-associated cells and effector mechanisms for host protection. Dr. Arulanandam's laboratory is focused on understanding the basic mechanism(s) of immune defenses at mucosal sites. The specific ongoing projects include the following:
Immunopathogenesis of Chlamydia trachomatis
There currently is no licensed vaccine against Chlamydia trachomatis, the leading cause of sexually transmitted bacterial disease worldwide. They are currently investigating various aspects of Chlamydia-induced pathogenesis utilizing genital and lung bacterial challenge models. The pathology produced by both genital (e.g., PID) and pulmonary infection of newborns (asthma-like consequences such as airway hyper-reactivity) result as a consequence of immunological sequel to the primary or repeated infections with this pathogen.
Respiratory Defenses against Pulmonary Tularemia
Francisella tularensis is an intracellular Gram-negative bacterium that is the causative agent of tularemia. Inhalation of F. tularensis results in severe disease and a high fatality rate in humans. His laboratory has recently shown the involvement of mast cells in early defenses against pulmonary tularemia. They are currently examining the mechanism(s) by which mast cells modulate innate immune defenses against this pathogen, and as a model for other Gram negative bacteria. Moreover, they are characterizing the use of defined F. tularensis mutants as live attenuated vaccine candidates against pneumonic tularemia.
Mucosal Defenses against Acinetobacter baumannii
Acinetobacter baumannii has emerged as an important nosocomial pathogen. There is evidence to suggest that gastrointestinal colonization of A. baumannii in humans precedes the onset of other clinical conditions such as septicemia, pneumonia and wound sepsis, with little known about the interaction of this pathogen with the gastrointestinal (GI) tract. They have developed an oral-gastrointestinal (GI) challenge model with A. baumannii to examine the contribution of mucosal immune defenses against gastrointestinal colonization by this pathogen and the subsequent systemic manifestation of this infection.
- Fellow of the American Association for Advancement of Science (AAAS)- Biological Sciences, 2014
- Vaccine Council Member of 100, International Society of Vaccines
- University of Texas System, Chancellor's Entrepreneurship and Innovation Award, 2010
- University of Texas at San Antonio, President's Distinguished Achievement Award for Research, 2010
Societal Affiliations/Boards- Professional Societies
- The Royal Society of Medicine
- Scientific Research Society Sigma Xi
- National Honor Society Phi Kappa Phi
- International Cytokine Society
- Society for Mucosal Immunology
- American Association of Immunology
- American Society of Microbiology
- Chlamydia Basic Research Society
- Infection & Immunity Editorial Board
- Vaccine: Development and Therapy
- Open Vaccine Journal
- Frontiers in Microbial Immunology-Review Editor
- Rodriguez, A. R., Plascencia-Villa, G., Witt, C. M., Yu, J. J., Jose-Yacaman, M., Chambers, J. P., Perry, G., Guentzel, M. N., and Arulanandam, B. P. (2015) Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells. Cellular immunology 295, 83-91.
- Gupta, R., Arkatkar, T., Yu, J. J., Wali, S., Haskins, W. E., Chambers, J. P., Murthy, A. K., Bakar, S. A., Guentzel, M. N., and Arulanandam, B. P. (2015) Chlamydia muridarum infection associated host MicroRNAs in the murine genital tract and contribution to generation of host immune response. Am J Reprod Immunol 73, 126-140.
- Arkatkar, T., Gupta, R., Li, W., Yu, J. J., Wali, S., Neal Guentzel, M., Chambers, J. P., Christenson, L. K., and Arulanandam, B. P. (2015) Murine MicroRNA-214 regulates intracellular adhesion molecule (ICAM1) gene expression in genital Chlamydia muridarum infection. Immunology 145, 534-542.
- Wali, S., Gupta, R., Veselenak, R. L., Li, Y., Yu, J. J., Murthy, A. K., Cap, A. P., Guentzel, M. N., Chambers, J. P., Zhong, G., Rank, R. G., Pyles, R. B., and Arulanandam, B. P. (2014) Use of a Guinea pig-specific transcriptome array for evaluation of protective immunity against enital chlamydial infection following intranasal vaccination in Guinea pigs. PloS one 9, e114261.
- Ketter, P. M., Guentzel, M. N., Schaffer, B., Herzig, M., Wu, X., Montgomery, R. K., Parida, B. K., Fedyk, C. G., Yu, J. J., Jorgensen, J., Chambers, J. P., Cap, A. P., and Arulanandam, B. P. (2014) Severe Acinetobacter baumannii sepsis is associated with elevation of pentraxin 3. Infection and immunity 82, 3910-3918.
- Trivedi, N. H., Guentzel, M. N., Rodriguez, A. R., Yu, J. J., Forsthuber, T. G., and Arulanandam, B. P. (2013) Mast cells: multitalented facilitators of protection against bacterial pathogens. Expert review of clinical immunology 9, 129-138.
- Li, W., Murthy, A. K., Lanka, G. K., Chetty, S. L., Yu, J. J., Chambers, J. P., Zhong, G., Forsthuber, T. G., Guentzel, M. N., and Arulanandam, B. P. (2013) A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice. Vaccine 31, 5722-5728.
- Sanapala, S., Yu, J. J., Murthy, A. K., Li, W., Guentzel, M. N., Chambers, J. P., Klose, K. E., and Arulanandam, B. P. (2012) Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida DfopC vaccine strain. Infection and immunity 80, 2177-2185.
- Jupelli, M., Murthy, A. K., Chaganty, B. K., Guentzel, M. N., Selby, D. M., Vasquez, M. M., Mustafa, S. B., Henson, B. M., Seidner, S. R., Zhong, G., and Arulanandam, B. P. (2011) Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. Laboratory investigation; a journal of technical methods and pathology 91, 1530-1539.
- Ketavarapu, J. M., Rodriguez, A. R., Yu, J. J., Cong, Y., Murthy, A. K., Forsthuber, T. G., Guentzel, M. N., Klose, K. E., Berton, M. T., and Arulanandam, B. P. (2008) Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proceedings of the National Academy of Sciences of the United States of America 105, 9313-9318.
This material is based upon the work supported by the Army Research Office of the Department of Defense under Contract No. W911NF-11-1-0136