Primary Faculty and their Research Programs
*Members of the Graduate Faculty are available as mentors to graduate students.
Host-mycoplasma interplay; Mechanisms of cytadherence; Invasion; Intracellular persistence; Molecular basis of virulence; Toxin-mediated cytopathology; Gene regulation
Host-pathogen interactions; Yersinia pseudotuberculosis, CD8+ T cell responses; apoptosis; phagocytosis, gastrointestinal infection
Cytokine and Toll-like receptor signaling; immunity to infection; Francisella tularensis; interleukin-4
Host antiviral defense mechanism: innate immune antiviral and inflammatory response against respiratory RNA viruses like human respiratory syncytial virus (RSV), influenza A virus and parainfluenza viruses; virus based anti-cancer therapeutics.
Bacterial host-pathogen interaction in vivo; inflammation; cytokine response; Yersinia; asthma, inflammatory T-cell responses
Control of filamentous growth and virulence in the major fungal pathogen Candida albicans; identification and characterization of novel C. albicans virulence factors; transcriptional regulation; C. albicans genomics
Our research group studies how human pathogenic bacteria like Mycoplasma pneumoniae and Mycoplasma genitalium cause disease.
Bacterial genetics; virulence mechanisms in periodontal pathogens; transcriptional regulation; function of microbial surface layer proteins
Immunobiology; Autoimmune disease; Two-way communication between the immune system and autoimmune target tissues; Immune and muscle responses in Myasthenia Gravis
Poxvirus pathogenesis and immune modulation; virus-host interactions
Use of comparative genomics to identify differences between invasive and non-invasive clinical isolates of Streptococcus pneumoniae; Identification of novel virulence determinants and assessment of their vaccine potential
Mucosal immunology, with two directions: (1) genitalmucosal transmission of HIV, and (2) thyroid hormone control of intestinal epithelial cell homeostasis (selfrenewal of stem cells, transit amplification of these cells to cover the intestinal villi, differentiation, defense responses to pathogens, and malignant transformation)
Medical mycology; molecular mechanisms of fungal pathogenesis, mating and development in Cryptococcus neoformans, Candida albicans biofilms molecular biology, animal models of invasive aspergillosis
Poxvirus pathogenesis and immune modulation; virus-host interactions; protein structure-function
Molecular basis of Chlamydia-host interactions; Chlamydiae pneumoniae in atherosclerosis; Proteomics analysis of chlamydial hypothetical proteins; Vaccine development