Research | Publications | Awards | Posters & Presentations
Su Yu Tsai
Bose lab - STRF: 293.1 A-F Tel: (210) 562-4170Fax: (210) 562-4191Email:
B.S. - Tunghai University
Damage-Associated Molecular Patterns (DAMPs) are molecules released by cells upon appropriate stimuli that act as danger signals to induce and regulate immune responses. Several DAMPs have been known to play an important role in inflammation. S100A9, one of DAMPs, is a small calcium-binding protein expressed prominently in cytosol of neutrophils and monocytes. During inflammation, S100A9 is released into the extracellular environment and acts as a alarm to induce host immune responses. Increased S100A9 levels are associated with progression of multiple inflammatory diseases, including cystic fibrosis and rheumatoid arthritis. However, whether DAMPs are also involved in lung inflammation during influenza A virus infection is not clear. Therefore, in this proposal, we will examine 1) Secretion of S100A9 during influenza A virus infection, 2) Function of extracellular S100A9 in promoting inflammation upon influenza A virus infection and 3) Role of extracellular S100A9 in lung pathogenesis during influenza A virus infection in mouse model. Since Influenza A virus infection causes a high annual mortality worldwide, it is important to investigate pro-inflammatory activity of S100A9 in massive lung inflammation during infection. Clarifying functions of released/secreted S100A9 in lung pathogenesis will provide us clues in developing better treatments against influenza A virus.