Research | Awards and Accomplishments
Bergman lab - STRF: 275.1 G-L Tel: (210) 562-4173
Fax: (210) 562-4191
In the United States, lung infections cause more morbidity and mortality than any other disease. Serratia marcescens, a highly antibiotic resistant bacterium is an important emerging pathogen that causes a wide range of diseases, rapidly spreads in hospitals and has a high mortality rate. A recent study showed that Serratia spp. (mainly S. marcescens) are one of the most common causes of pneumonia in the US, Europe and Latin America and is among the top ten most common causes of bloodstream bacterial infections in North America. Despite the documentation and descriptions of clinical symptoms and histopathology of S. marcescens pneumonia cases, the molecular and cellular mechanisms underlying bacterial pathogenesis and host immune responses are completely unknown. To bridge these gaps we have developed a novel mouse model of S. marcescens pneumonia that intrinsically mimics human infection and has brought light on how the host cellular responses react upon infection. During these studies we found that a previously described virulence determinant of S. marcescens, the hemolysin ShlA/B, has an important role during infection. However, the mechanisms of how this toxin causes disease and cell death during pneumonia are currently being studied in our lab.
Scholar, Initiative for Maximizing Student Development Training Grant R25, PI. Nicquet Blake
Best Student Poster Presentation: Infectious Diseases UTSA Research Conference
Best Graduate Student Poster Presentation: San Antonio Vaccine Development Center Symposium
Third Best Graduate Student Poster, Microbiology and Immunology department retreat.
Recipient, Translational Science Training Scholar, Institutional National Research Service Award. PD. Linda McManus.
American Society of Microbiology (ASM)
Society for Advancement of Chicanos and Native Americans in Science (SACNAS)
American Association of Immunologists (AAI)
Gonzalez-Juarbe N, Mares CA, Hinojosa CA, Medina J, Dube P, Orihuela CJ, Bergman MA. A New Murine Model of Serratia marcescens Nosocomial Pneumonia: Importance of Host Neutrophils and Bacterial Cytolysin. Submitted manuscript, Feb 2014
Hinojosa CA, Gonzalez-Juarbe N, Ferdandes G, Bergman MA, Orihuela CJ. Dietary n-3 polyunsaturated fatty-acids reduce lung inflammation during experimental pneumococcal pneumonia. In preparation.
Hobbies: Wood crafting and Puerto Rico cultural music.
Interests: Lung diseases and Inflammation, Bacterial Pathogenesis, Immunology, Innate Immunity