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Patterson Lab - TX Biomedical Research InstituteTel: (210) 258-9431Fax: (210) 670-3329Email:
Marburgvirus (MARV) a member of the family Filoviridae, causes hemorrhagic fever in humans and primates. Case fatality rates in previous MARV hemorrhagic fever outbreaks have ranged from 23% to 83%. The bleeding disorders and vascular leakage observed during infection indicate disrupted epithelial-barrier functions, which are mainly regulated by intercellular junctions referred to as adherens junctions (AJs) and tight junctions (TJs).
The objective of my research is to investigate changes in the components of AJs (E-cadherin) and TJs (Occludin and Claudin-1) after MARV infection. Preliminary indicate that certain virus proteins are sufficient to induce a dysregulation of junctional proteins in cell culture. Further experiments are planned to elucidate the mechanism of action of the down-modulation.