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Kadosh Lab - Room 5.023V Tel: (210) 567-3948Fax: (210) 567-6612Email:
Jordan University of Science and Technology, Jordan. Bachelor in Medicine and Bachelor in Surgery
Candida albicans, a diploid dimorphic fungus, is part of the normal flora of the oral cavity, gastrointestinal and genitourinal tracts of healthy individuals. C. albicans is the most common opportunistic fungal pathogen in humans, causing both mucosal and widespread systemic infections. Immunocompromised individuals, such as cancer patients on chemotherapy, organ transplant recipients and patients with indwelling catheters, can develop disseminated candidiasis, a systemic form of the disease with an approximately 40% mortality rate.
Our lab studies the ability of C. albicans to undergo a morphological switch from single oval-shaped cells (yeast) into elongated cells attached end-to-end (pseudohyphal and hyphal filaments). Hyphal filaments are associated with virulence and a variety of virulence-related properties including tissue invasion, lysis of macrophages and breaching of endothelial cells. Various host environmental cues are known to induce the C. albicans yeast-hyphal transition via coordinated expression of a transcriptional program. My work focuses on gaining a better understanding of the molecular mechanisms that control C. albicans morphology, virulence, filamentous growth regulatory circuits and signaling pathways.
American Society of Microbiology
American Medical Association