Orihuela lab - STRF: 275.1 A-F
Tel: (210) 562-4172
Fax: (210) 562-4191
B.S. Microbiology - University of Texas at Austin Austin, TX 2004-2009
Post-Baccalaureate Baylor College of Medicine - Houston, TX 2009-2010
PhD Microbiology - Univ. of Texas H.S.C. at San Antonio - San Antonio, TX 2010-Present
I am currently a fourth year Ph.D. Candidate in the Department of Microbiology and Immunology working in the laboratory of Dr. Carlos J. Orihuela Ph.D. My project is focused on investigating the interactions between Streptococcus pneumoniae (the pneumococcus)and cardiomyocytes during invasive pneumococcal disease (IPD). Previously, I have implicated the pneumococcal surface adhesin choline-binding protein A (CbpA) and the host platelet activating factor (PAFr) in cardiac tissue invasion, and lesion formation. Current studies are focus on the molecular mechanism(s) responsible for cardiomyocyte death as a result of these interactions.
2009 Trainee, Human Genome Sequencing Center (HGSC)-Genetics/Genomics Research
Education and Training (GREAT) Summer Research Program, BCM, Houston, TX.
2009-2010 Trainee, HGSC-Post Graduate Education Training (PGET), Post-Baccalaureate Program, BCM, Houston, TX.
2013 Travel Award to the 2013 American Society for Microbiology (ASM) General Meeting. Denver, CO.
2013-Present Translational Science Training (TST) Fellow - UTHSCSA.
2013-Present Ruth L. Kirschstein National Research Service Award (F-31) Predoctoral Fellow - NRSA
2014 Travel Award to The fifth International Conference on Gram-Positive Pathogens
Patents UTHSCSA (May 2013)
Co-Inventor: YLN, a CbpA/Pneumolysin conjugate vaccine for protection against cardiac damage incurred during invasive pneumococcal disease.
Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ.(2014) Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function. PLoS Pathog 10(9): e1004383. doi:10.1371/journal.ppat.1004383.
Brown AO and Orihuela CJ. Visualization of Streptococcus pneumoniae within cardiac microlesions and cardiac remodeling. (In Press. JOVE 2014).
Brown AO, Quint J, Orihuela CJ. Bacteria mediated cardiac dysfunction during community-acquired pneumonia. (Manuscript in prep. American Journal of Respiratory and Critical Care Medicine2014). (In Review)
Brown AO, Nikhil K, Tettelin H, Orihuela CJ. Pneumococcal gene expression during cardiac microlesion development. (Manuscript in prep.)