Research | Publications | Curriculum vitae (Pdf format) | Biosketch (Pdf format)
T. R. Kannan, Ph.D.
STRF - Room 289.5 Tel: (210) 562-4182Fax: (210) 562-4171Email:
Our research group studies how human pathogenic bacteria like Mycoplasma pneumoniae and Mycoplasma genitalium cause disease. In particular we study the virulent determinants used by these pathogens that facilitate them to subvert the host defenses. This research may lead to new strategies to prevent or treat infections.
Using lung surfactant protein-A as bait we identified an ADP ribosylating and vacuolating cytotoxin of M. pneumoniae and designated community acquired respiratory distress syndrome (CARDS) toxin. Specific projects include the molecular characterization of CARDS toxin of M. pneumoniae and similar toxins of other mycoplasma. In addition, we study virulence genes expression, nuclear tropism/modulation and persistence of M. pneumoniae and M. genitalium.