Research | Publications | Lab Members
Subramanian Dhandayuthapani, Ph.D.
RAHC Medical Research Division
1214 W. Schunior St.
Edingburg, TX 78359
Tel: (956) 393-6431Fax: (956) 393-6402Email:
Research Interests: My laboratory primarily studies the pathogenic mechanisms of Mycobacterium tuberculosis and Mycoplasma genitalium.
M. tuberculosis is the etiological agent of human 'tuberculosis' which has the ability to survive and replicate inside hostile macrophages, and to lead a dormant life
inside 'tubercle lesions'. M. genitalium is a sexually transmitted pathogen which survives and persists within host epithelial cells.
I employ multiple approaches to dissect the mechanisms behind intracellular survival and persistence of both species.
Some important projects addressing these issues are: a) role of antioxidants of M. tuberculosis and M. genitalium in the evasion of host generated oxidative radicals, b)
role of signal transduction and regulatory molecules of M. tuberculosis and M. genitalium in the persistence of these species, and c) modulation of host microRNA by
M. tuberculosis and M. genitalium. In addition, my laboratory also focuses on the development of genetically engineered vaccines to tuberculosis (TB).
This includes the improved BCG vaccines through recombinant technology, generation of M. tuberculosis vaccine candidates by genetic modifications, and development
of recombinant booster vaccines to TB using bacillus spores. Last but not least, my laboratory also studies the interaction of M. genitalium with HIV-1. Lately, M. genitalium
is considered an important cause of HIV-1 transmission.
Regional Academic Health Center