Research | Publications | Lab Members
Peter H. Dube, Ph.D.
STRF - Room 289.4
Tel: (210) 562-4181
Fax: (210) 562-4191Email:
Infectious diseases remain the number one killer of people worldwide and the recent emergence and re-emergence of serious human pathogens suggest that this trend will continue. Often the morbidity and mortality associated with infectious diseases can be directly linked to inflammation. Even with the great advances in immunology over the last twenty years, the pathogenesis of most infectious diseases remains poorly understood. This creates a significant problem in human health as many pathogens are now becoming resistant to current therapeutics.
The research in the laboratory focuses on the immuno-biology of infectious disease. Our interests are in innate and adaptive immunity, inflammation, and pathology due to inflammation. Our main goal is to understand how bacterial pathogens interact with mucosal surfaces of the host to cause disease. Understanding the cross talk between pathogens and the host is the key to unlocking the molecular mechanisms of disease and ultimately therapeutic intervention. To accomplish this goal, we study three pathogens Yersinia enterocolitica, Yersinia pestis, and Mycoplasma pneumoniae and their interactions with the gut and the lung respectively.
Our work directly examines the molecular mechanisms underlying a number of serious human diseases including food borne infections, pneumonia, allergy, and asthma. We take a multi-disciplinary approach to solving complex problems integrating techniques in animal modeling, molecular genetics, molecular and cellular immunology, biochemistry, and cell biology.
Much of the work in lab investigates the roles of various cytokines and chemokines in the pathogenesis of disease. How these important signaling molecules are regulated during infection and the role of virulence factors in the modulation of cytokine responses leading to pathology is central to our understanding of disease. Recently we have begun to explore the the generation of allergic inflammation in response to infection.
Complete List of Publications