Research | More on M. Neal Guentzel
M. Neal Guentzel, Ph.D.
The University of Texas at San Antonio
Department of Biology
Tel: (210) 458-4473Fax: (210) 458-5658Email:
I collaborate with Dr. Bernard Arulanandam at the University of Texas at San Antonio on a variety of research projects. This work is primarily on pathogenesis, host responses (both innate and adaptive immunity) and vaccine development for the important human pathogens Francisella tularensis, a select agent and the cause of tularemia in humans, and Chlamydia trachomatis, the major bacterial sexually transmitted pathogen. This work has defined a protective role for mast cells in control of intracellular F. tularensis replication, established the efficacy of experimental vaccines for tularemia, and recently defined complementary pathways to M cells for oral vaccine uptake. Our studies have helped to define the mechanisms for upper genital tract pathology and infertility following Chlamydia infection; and severe respiratory sequelae in adults following pulmonary infection with Chlamydia as neonates. We also study other important pathogens, including Acinetobacter baumanii, a primary wound and sepsis pathogen of the US military and an important emerging nosocomial pathogen in the civilian population, which is particularly difficult to treat because of multi-drug resistance and high mortality rate. We have established colonization and sepsis models to study the mechanisms of pathogenesis, and have identified markers associated with severe disease. We also are doing some work on obesity and diabetes and the role of infection in beta cell function. The first manuscripts from these latter two areas of research have recently been submitted.
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