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CTRC researcher part of multiteam European cancer project

Posted: Tuesday, January 21, 2014 · Volume: XLVII · Issue: 2

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Tyler Curiel, M.D., is leading one of the seven teams working on the $8 million, international project to develop a new drug that could potentially fight many types of cancer.

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Tyler Curiel, M.D., is leading one of the seven teams working on the $8 million, international project to develop a new drug that could potentially fight many types of cancer. Click on image to make it larger. clear graphic

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Contact: Elizabeth Allen, 210-450-2020

SAN ANTONIO (Jan. 15, 2014) — A Cancer Therapy & Research Center (CTRC) researcher has won a grant to be part of an ambitious multimillion-dollar international program to develop a new drug that could potentially be used to fight many different cancers.

Tyler Curiel, M.D., M.P.H., an internationally known cancer immunologist at the CTRC, part of The University of Texas Health Science Center at San Antonio, is part of the TumAdoR project. Dr. Curiel also is a professor in the School of Medicine at the Health Science Center.
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The project grants $8 million among the researchers over four years to develop an antibody that will block a specific cancer metabolic pathway and reduce its ability to suppress the immune system. The objective is to have the antibody developed and ready for clinical trials at the end of the grant period.

“It can take decades to be in a clinical trial with a new concept and we’re trying to do it in four years,” Dr. Curiel said. “I think we’ve got a pretty good shot.”

Developing animal models for research
Dr. Curiel is the leader for TumAdoR Project 6, funded at $800,000. His team’s mission is to develop mice with human immune systems and other models and additional tests to be sure that the developed antibody can block the metabolic pathway, and to assess what the immune consequences will be in humans.

The TumAdoR project weaves together the skills of seven different teams from Germany, Switzerland, France, Finland and the UT Health Science Center to attack the problem from multiple perspectives such as immunology, drug development, and clinical trial design and management.

Supressing CD73 enzyme
Its target is CD73, an enzyme that is overexpressed in many different kinds of cancer. CD73 helps produce excess amounts of adenosine, which is needed to produce energy in cells, but also can suppress the immune system and allow the tumor cells to reproduce.

Adenosine is not normally immune-suppressive, “but it is when you generate lots of it, as tumors do. Tumors do everything in a crazy way,” Dr. Curiel said.

Potential to fight several types of cancer
Antibody therapy is already a proven success — one example is Herceptin, an antibody drug used to treat breast cancer — but the promising thing about this project is that the drug may well work against several types of cancer.

Bin Zhang, M.D., Ph.D., a former CTRC researcher who developed critical CD73 data, now at Northwestern University, remains a part of the Curiel team collaborating on Project 6.

Christophe Caux, PhD, at the Léon Bérard Cancer Center in Lyon, France, is principal investigator.

The TumAdoR project receives funding from the European Union's 7th Research Framework Programme (FP7).

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The Cancer Therapy & Research Center (CTRC) at The University of Texas Health Science Center at San Antonio is one of the elite academic cancer centers in the country to be named a National Cancer Institute (NCI)-designated Cancer Center, and is one of only four in Texas. A leader in developing new drugs to treat cancer, the CTRC Institute for Drug Development (IDD) conducts one of the largest oncology Phase I clinical drug programs in the world, and participates in development of cancer drugs approved by the U.S. Food & Drug Administration. For more information, visit www.ctrc.net.

 
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