Department of Cellular and Structural Biology

CSB Faculty Research Interests

 

Bai, Yidong, Ph.D. Mitochondrial genetics, aging, cancer and mitochondrial medicine.

 

Bandyopadhyay, Abhik, Ph.D. Mammary stem cell biology and generation of breast cancer stem cells, Aging and breast cancer, Pre-clinical assessment of targeted molecular therapeutics.

 

Bishop, Alex, Ph.D. Systems biology and homologous recombination in carcinogenesis, DNA repair, functional genomics, genetic and environmental interactions, aging, carcinogenesis, animal models.

 

Dong, Lily Q., Ph.D. Obesity and Type 2 Diabetes.

 

Du, Liqin, Ph.D. Pediatric cancers, Mechanisms of neuroblastoma cell differentiation, Differentiation therapy in neuroblastoma, Cancer stem cell biology.

 

Habib, Samy, M.S., Ph.D. Role of diabetes in development of cancer, molecular mechanisms of the DNA damage and repair in diabetes and cancer, Role of Tuberin/mTOR pathways in regulation of cell proliferation, cell hypertrophy and cell apoptosis.

 

Kokovay, Erzsebet, Ph.D. Adult neural stem cells and neurogenesis.

 

Kraig, Ellen, Ph.D. Aging, Immunity, Maternal nutrition, Autoimmunity, Inflammation.

 

Larsen, Pamela L., Ph.D. Development and aging in C. elegans. Molecular genetics, expression analysis, functional genomics, genetic and environmental interactions and C. elegans physiology.

 

Leach, Robin J., Ph.D. Genetics of complex diseases. Development and validation of biomarkers for cancer.

 

Lechleiter, James D., Ph.D. Molecular and cellular mechanisms of protection during ischemic stress, acute brain injury and aging.

 

Marciniak, Robert A., M.D., Ph.D. Aging, mechanisms of telomere maintenance, Werner syndrome and cell regulation.

 

Moore, Charleen M., Ph.D. Comparative cytogenetics, and history of medicine.

 

Oyajobi, Babatunde O., M.B., B.Ch., Ph.D. Bone biology and cancer-induced bone diseases.

 

Penalva, Luiz Otavio F., Ph.D. Molecular analysis of cancer, post-transcriptional regulation, RNA binding proteins, cancer genomics, alternative splicing.

 

Ran, Qitao, Ph.D. Oxidative stress in Alzheimer's disease and aging; Mitochondrial dysfunction in Alzheimer's disease and aging; Rodent models for neurodegeneration and aging research.

 

Rao, Manjeet, Ph.D. miRNA : Development and Cancer, Epigenetics and Cancer stem cell, Functional genomics, animal models.

 

Rebel, Vivienne, M.D., Ph.D. Molecular mechanisms of hematopoietic stem cell regulation, from development to old age.

 

Reiter, Russel J., Ph.D. Melatonin in free radical biology and oxidative stress, aging, antioxidants and the pineal gland.

 

Sakaguchi, Alan Y., Ph.D. Oncogenes & tumor suppressor genes, telomere binding proteins, cell aging, cell rejuvenation.

 

Sharma, Ramaswamy, Ph.D. Osteoporosis, Mesenchymal Stem Cells, Regenerative Medicine, Apoptosis, Aging.

 

Sun, LuZhe, Ph.D. Role of growth factors, steroid hormones, telomerase, and adhesion molecules in cell proliferation, senescence, apoptosis, tumor angiogenesis and metastasis of human breast, prostate and liver cancer cells;        Translational research using recombinant growth factor binding proteins, small growth factor inhibitors, and chemotherapeutics to inhibit tumor growth, angiogenesis and metastasis;        Effects of age, xenoestrogens, obesity, radiation, and mutagens on mammary stem cell function and transformation.

 

Tardif, Suzette, Ph.D. Primate models of obesity and aging. Reproductive energetics, pregnancy & lactation and maternal obesity.

 

Vogel, Kristine S., Ph.D. Signal transduction, tumorigenesis in the peripheral nervous system. Mouse models for nervous system tumors, Apoptosis in the sympathoadrenal lineage, DNA damage and repair in the peripheral nervous system, Regulation of Nf1 gene expression during development, Adapting innovative technologies for medical education in the basic sciences.

 

Walter, Christi A., Ph.D. DNA repair and mutagenesis,paternal age effect, stem cell aging, hepatocellular carcinoma, responses to mitochondrial DNA damage.

 

Wang, Pei, Ph.D. To recapitulate the pathogenesis of Pancreatic ductal adenocarcinoma (PDAC) in vitro and in vivo to identify markers and methods for early diagnosis of PDAC and to inform the development of effective therapeutic strategies. To generate insulin producing cells and liver cells from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSC) for modeling disease and for cell replacement therapies.

 

Watts, Lora, Ph.D. Traumatic Brain Injury, Stroke, Neuroprotection, Mitochondrial dysfunction, Novel therapeutics.

 

CSB Joint Appointed Faculty Research Interests:

Bone-targeted drugs as potential treatments for multiple myeloma, experimental therapeutics, organic chemistry.
Bone metastases, prostate cancer, bladder cancer, animal models of cancer-induced bone diseases, experimental therapeutics, tumor suppressor genes.