Department of Cellular and Structural Biology

CSB Faculty


Earlanda L. Williams, Ph.D.

Lecturer III


University of Texas Health Science Center San Antonio, 2009


Dental 1.236S
(210) 567-3926


Dr. Williams' research has focused on the molecular mechanisms responsible for immune tolerance to the acetylcholine receptor (AChR), the autoantigen in myasthenia gravis (MG). Studies using a transgenic mouse model have shown that peripheral expression (muscle only) of the AChR is sufficient to induce T cell tolerance, while central (thymic) expression is dispensable. Further investigations have revealed a role for Foxp3+CD25+ T regulatory cells as important mediators of T cell tolerance to the AChR in this model.
As an elected member of the American Association of Anatomist Advisory Committee for Young Anatomists, Dr. Williams current interests include anatomy education and the development of innovative techniques for teaching the anatomical sciences.


Dr. Williams is the course director for Dental Gross Anatomy (CSBL 5016) and Anatomy II (CSBL 8010) for first-year dental and third-year physical therapy students, respectively. She is also a co-director for the newly implemented Interprofessional Anatomy (CSBL 5022) for occupational therapy, physical therapy, physician assistant, biomedical engineering and graduate students.


Dr. Williams has been the recipient of several teaching honors including a Presidential Teaching Excellence Award (2014), induction into the UTHSCSA Academy of Master Teachers (2014) and the CSB Excellence in Health Professional Student Education Award (2012).

Representative Publications:
Stacy S, Williams EL, Standifer NE, Pasquali A, Krolick KA, Infante AJ, Kraig E. Maintenance of immune tolerance to a neo-self acetylcholine receptor antigen with aging: implications for late-onset autoimmunity. J Immunol. 2010 Jun 1;184(11):6067-75.


Kazianis S, Nairn RS, Walter RB, Johnston DA, Kumar J, Trono D, Della-Coletta L, Gimenez-Conti I, Rains JD, Williams EL, Pino BM, Mamerow MM, Kochan KJ, Schartl M, Vielkind JR, Volff JN, Woolcock B, Morizot DC. The genetic map of Xiphophorus fishes represented by 24 multipoint linkage groups. Zebrafish. 2004;1(3):287-304


Kazianis S, Khanolkar VA, Nairn RS, Rains JD, Trono D, Garcia R, Williams EL, Walter RB. Structural organization, mapping, characterization and evolutionary relationships of CDKN2 gene family members in Xiphophorus fishes. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul;138(3):291-9.


Additional Publications:
Sakaguchi A, Bartanuszova M, Williams E, Moore C. (2014) The Anterior Abdominal Wall: A Self-Study Paper Model. MedEdPORTAL; 2014.


Williams, E., S. Stacy, A.J. Infante, and E. Kraig (2009) Chapter 13. Mechanisms of tolerance in experimental models of myasthenia gravis. In P. Christadoss (ed.), Myasthenia gravis (pp. 235-257).


Walter RB, Rains JD, Russell JE, Guerra TM, Daniels C, Johnston DA, Kumar J, Wheeler A, Kelnar K, Khanolkar VA, Williams EL, Hornecker JL, Hollek L, Mamerow MM, Pedroza A, Kazianis S. (2004) A microsatellite genetic linkage map for Xiphophorus. Genetics. 2004 Sep;168(1):363-72.