Pei Wang, Ph.D.Assistant Professor
Baylor College of Medicine, 2004
MED 2.054 1/2 V
- 1) to understand the role of Hippo pathway in the pathogenesis of PDAC,
- 2) to identify the factors in orchestra with mutant KRAS to transform pancreatic intraepithelial neoplasia (PanIN) to PDAC, and
- 3) to study the pancreatic stromal cells in PDAC.
Other interests of my lab include the study of signaling pathways involved in beta-cell development and function, and also to generate insulin producing cells (IPCs) from pluripotent stem cells for modeling disease and for cell replacement therapies for diabetes.
Dr. Wang also participates in teaching the basics of stem cells for the graduate school core course INTD5000 regenerative medicine module. She also gives a lecture in the "stem cell and regenerative medicine" course.
Wang P, McKnight KD, Wong DJ, Rodriguez RT, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang HY, Kim SK. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 2012 Aug 10;21(12):2273-87.
Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 2011 Jun 5;43(7):621-9.
Wang R, Tang P, Wang P, Boissy RE, Zheng H. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):353-8.
Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4679-84.
McKnight KD, Wang P, Kim SK. Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell. 2010 Apr 2;6(4):300-8.
Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H.
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.
J Neurosci. 2005 Feb 2;25(5):1219-25.
Jun Liu, Ph.D from Creighton University
Han Wang, Ph.D from Ohio University
Naoki Akanuma, MD. Ph.D from Chiba University, Japan
Kunhua Qin, 2012
Ming Gao, 2013
Xie Luo, from Xiangya Medical school, China
Jake Leighton, graduated from UT Austin