Department of Cellular and Structural Biology

CSB Faculty


Kristine S. Vogel, Ph.D.

Assistant Professor


University of Oregon, 1988


Med 235D
(210) 567-0259


Recently, I made the transition from developing and characterizing mouse models for tumors associated with neurofibromatosis type 1 (NF1), to using Schwann cells isolated from NF1 patient neurofibromas, in order to identify mechanisms contributing to variable expressivity in this disease. Based on molecular genetics investigations, DNA damage sensitivity and repair characteristics have been proposed to contribute to the differences in disease severity, particularly in the numbers and types of of tumors, observed in individuals with NF1. We are addressing this hypothesis directly by comparing DNA damage repair parameters in neurofibroma-derived Schwann cells, and by performing retrospective chart reviews for NF1 patients enrolled in the study. Our goal is to identify possible interventions to reduce tumor burden, and to keep individuals with NF1 healthy as they grow older.


  • CIRC 6007 Mind, Brain & Behavior, Module Co-Director
  • CSBL 5020 Dental Neuroscience, Course Director
  • CSBL 4017 Advanced Neuroanatomy, Course Director
  • CIRC 5003 Language of Medicine, Instructor
  • CSBL 5016 Dental Gross Anatomy, Instructor
The Neurology co-director for CIRC 6007, Dr. Diane Solomon, and I collaborated with my research colleague, Dr. Vic Riccardi, to develop a Gait and Mobility laboratory session. In this session, the medical students not only learn the neuroanatomy and clinical assessment of spinal cord injuries, but also interact with a patient (who is also a physician), and ask questions about his extraordinary narrative, rehabilitation, and coping skills. We have presented this laboratory in two Education Showcases here at UTHSCSA.


Recent Publications:
Dao V, Yeh PH, Vogel KS, Moore CM. (2015) Applied neuroanatomy elective to reinforce and promote engagement with neurosensory pathways using interactive and artistic activities. Anat Sci Educ. 2015 Mar-Apr;8(2):166-74.


Vogel KS, Perez M, Momand JR, Acevedo-Torres K, Hildreth K, Garcia RA, Torres-Ramos CA, Ayala-Torres S, Prihoda TJ, McMahan CA, Walter CA. (2011) Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice. Mol Reprod Dev. 2011 Dec;78(12):906-19.


Xu G, Vogel KS, McMahan CA, Herbert DC, Walter CA. (2010) BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice. Biol Reprod. 2010 Dec;83(6):979-87.


Garza R, Hudson RA 3rd, McMahan CA, Walter CA, Vogel KS. (2007) A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1. Mutat Res. 2007 Feb 3;615(1-2):98-110.


Ling BC, Wu J, Miller SJ, Monk KR, Shamekh R, Rizvi TA, Decourten-Myers G, Vogel KS, DeClue JE, Ratner N. (2005) Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell. 2005 Jan;7(1):65-75.


Representative Publications:
Vogel KS, El-Afandi M, Parada LF. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci. 2000 Apr;15(4):398-407.


Vogel KS, Klesse LJ, Velasco-Miguel S, Meyers K, Rushing EJ, Parada LF. (1999) Mouse tumor model for neurofibromatosis type 1. Science. 1999 Dec 10;286(5447):2176-9.


Vogel KS, Brannan CI, Jenkins NA, Copeland NG, Parada LF. (1995) Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell. 1995 Sep 8;82(5):733-42.