Department of Cellular and Structural Biology

CSB Faculty

 

LuZhe Sun, Ph.D.

Professor

 

Rutgers University and
UMDNJ-Robert Wood Johnson Medical School, 1990

 

MED 2.020V-1
(210) 567-5746
Sunl@uthscsa.edu

 

My laboratory studies molecular mechanisms that regulate cancer development, growth, invasion, and metastasis, and novel experimental therapeutics for cancer prevention and treatment using molecular biology, cell biology, and bioinformatics techniques and animal model systems. Ongoing research projects include the investigation of how aging, obesity, radiation, and xenoestrogens may induce a tumorigenic phenotype of mammary stem cells and the investigation of the roles of transforming growth factor-beta (TGFβ), hedgehog, and androgen signaling pathways in various types of cancer. We are developing therapeutic approaches for the prevention of aging-associated breast cancer and for abrogating TGFβ, hedgehog, and androgen signaling pathways for the treatment of aggressive cancers including castration resistant prostate cancer.

 


Course Director:
  • Advanced Cell Biology (INTD 6007)
  • Advanced Cell and Molecular Biology (INTD 5007)
Lecturer:
  • Cancer Biology (CSBL 6068)
Recent Publications:
Mishra S, Lin CL, Huang TH, Bouamar H, Sun LZ. MicroRNA-21 inhibits p57Kip2 expression in prostate cancer. Mol Cancer. 2014 Sep 12;13:212.

 

Mu X, Lin S, Yang J, Chen C, Chen Y, Herzig MC, Washburn K, Halff GA, Walter CA, Sun B, Sun LZ. TGF-β signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells. PLoS One. 2013 May 21;8(5):e63436.

 

Dong Q, Wang D, Bandyopadhyay A, Gao H, Gorena KM, Hildreth K, Rebel VI, Walter CA, Huang C, Sun LZ. Mammospheres from murine mammary stem cell-enriched basal cells: clonal characteristics and repopulating potential. Stem Cell Res. 2013 May;10(3):396-404.

 

Lin S, Yang J, Elkahloun AG, Bandyopadhyay A, Wang L, Cornell JE, Yeh IT, Agyin J, Tomlinson G, Sun LZ. Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells. Mol Biol Cell. 2012 Apr;23(8):1569-81.

 

Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop AJ, Jackson J, Lozano G, Copland JA, Mu X, Sun B, Sun LZ. Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β). J Biol Chem. 2011 Dec 23;286(51):44023-34.

 

Representative Publications:
Mishra S, Deng JJ, Gowda PS, Rao MK, Lin CL, Chen CL, Huang T, Sun LZ. Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene. 2014 Jul 31;33(31):4097-106.

 

Wang D, Gao H, Bandyopadhyay A, Wu A, Yeh IT, Chen Y, Zou Y, Huang C, Walter CA, Dong Q, Sun LZ. Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands. Cancer Prev Res (Phila). 2014 Apr;7(4):445-55.

 

Gowda PS, Deng JD, Mishra S, Bandyopadhyay A, Liang S, Lin S, Mahalingam D, Sun LZ. Inhibition of hedgehog and androgen receptor signaling pathways produced synergistic suppression of castration-resistant prostate cancer progression. Mol Cancer Res. 2013 Nov;11(11):1448-61.

Dr. Sun's Lab:
    Abhik Bandyopadhyay, Ph.D. - Research Assistant Professor
    Qiaoxiang (Daisy) Dong, Ph.D. - Research Assistant Professor
    Janice (Jianhong) Deng - Instructor
    Junhua (Jun) Yang, M.S. - Special Project coordinator
Postdoctoral fellows:
    Hakim Bouamar, Ph.D. - Postdoctoral Fellow
Graduate students:
    Xiang Gu - Graduate student
Visiting students:
    Yuanshuo (Sherry) Shi - Visiting student
    Fuchuang Zhang - Visiting student
    Tai (Edison) Qin - Visiting student
    Xia (Summer) Lu - Visiting student