Department of Cellular and Structural Biology

CSB Emeritus Faculty

 

William W. Morgan, Ph.D.

Professor Emeritus
Distinguished Teaching Professor
Master Teacher

 

Indiana University, 1970

 

MORGAN@UTHSCSA.EDU

 

I retired from the Department of Cellular and Structural Biology at the University of Texas Health Science Center at San Antonio, Texas, March 1, 2011. I had been on the faculty there for over 40 years.

 

Before my retirement I had been the course director for Experimental Design and Data Analysis, course director for the interdisciplinary course in Neuroanatomy, and lecturer and laboratory instructor for Medical Microanatomy. I also taught Medical Biostatistics to second year medical students. I also served as the chair of the qualifying examination committee for both the Biology of Aging and the Cell and Molecular Biology research tracks in the Integrated Multidisciplinary Graduate Program. I also chaired the Department Promotions, Tenure and Appointments Committee.

 

Throughout my career I maintained an active research program with a focus in later years on the investigation of the role of caspase 2 in the neurodegeneration of the dopaminergic neurons in the substantia nigra of mouse models of human Parkinson's disease. In collaboration with the laboratories of Dr. Arlan Richardson and Dr. Holly Van Remmen, I also generated a number of transgenic mouse models for the study of aging. Recent publications related to that work are listed below.

 

In August, 2011, I returned to San Antonio to teach the first module of Medical Microanatomy. As an Adjunct Professor during the Fall of 2011, I also taught Experimental Design and Data Analysis as an online course. In February 2012 and 2013, I returned to San Antonio to teach Medical Biostatistics to second year medical students.

 

Since my retirement, I have devoted considerably more time to my avocation as an amateur paleontologist. I am currently writing a book entitled "A Collectors Guide to Crawfordsville, Indiana Crinoids". These fossils are world renown for the exceptional quality of their preservation. The book is essentially finished, and it is due to be sent to the publisher June 1, 2013. I am currently collecting material for additional paleontology-related books. I also give fossil-related presentations to various groups in the area.

 

My wife and I have completed the Cumberland County Master Gardeners and are members of the Friends of the Library. I was recently elected to the board of the Obed River Watershed Association. This group works on projects related to water quality and is involved in a lot of stream cleanup and restoration.

 

PUBLICATIONS:
Tiwari M, Lopez-Cruzan M, Morgan WW, Herman B. (2011) Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons. J Biol Chem. 2011 Mar 11;286(10):8493-506.

 

Tiwari M, Herman B, Morgan WW. (2011) A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity. Exp Neurol. 2011 Jun;229(2):421-8.

 

Biju K, Zhou Q, Li G, Imam SZ, Roberts JL, Morgan WW, Clark RA, Li S. (2010) Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease.
Mol Ther. 2010 Aug;18(8):1536-44.

 

Samano AK, Ohshima-Hosoyama S, Whitney TG, Prajapati SI, Kilcoyne A, Taniguchi E, Morgan WW, Nelon LD, Lin AL, Togao O, Jung I, Rubin BP, Nowak BM, Duong TQ, Keller C. (2010) Functional evaluation of therapeutic response for a mouse model of medulloblastoma. Transgenic Res. 2010 Oct;19(5):829-40.

 

Kalkonde YV, Morgan WW, Sigala J, Maffi SK, Condello C, Kuziel W, Ahuja SS, Ahuja SK. (2007) Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Res. 2007 Jan 12;1128(1):1-11.