Cellular and Structural Biology | Faculty
Department of Cellular & Structural Biology

CSB Faculty

 

Photo of Dr. Dashnamoorthy Ravi Dashnamoorthy, Ph.D.
Instructor / Research

 

Mahatma Gandhi University, 2002

 

GCCRI
(210) 562-9091
dashnamoorth@uthscsa.edu

 

Dr. Ravi Dashnamoorthy joined the department in 2008. He is a member of American Association for Cancer Research and American Physiological Society.

 

Research Interests: Cells respond to endogenous or exogenous damage to enable survival. Inappropriate cellular responses to damage could result in pathological changes leading to diseases, such as cancer. Moreover altered cellular responses to damage may interfere with the therapeutic efficacy of anticancer drugs, resulting in resistance to treatment. Therefore my interest is to understand the biology of cellular damage response in the context of carcinogenesis and cancer therapy. My long-term goal is to develop strategies for chemoprevention of cancer and to improve anticancer therapy.

 

Research Techniques:
Techniques relevant to analysis of DNA damage response, Red-ox biology, Signal transduction, Drug metabolism and Cancer biomarkers.
RNAi and HTS assays, Western blot, Gel mobility shift, Superoxide and protein redox status measurement, Apoptosis assays, Fluoresence microscopy and Immunocytochemistry.

 

PUBLICATIONS:
D Ravi, A Wiles, S Bhavani, J Ruan, P Leder, AJR Bishop. (2009)
A network of conserved DNA damage survival pathways revealed by a genomic RNAi screen.
PLoS genetics (Accepted 05/2009)

 

Ravi D, Muniyappa H, Das KC. (2008)
Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol Cell Biochem. 2008 Jan;308(1-2):193-200. Epub 2007 Oct 12.

 

Ravi D, Muniyappa H, Das KC. (2005)
Endogenous thioredoxin is required for redox cycling of anthracyclines and p53-dependent apoptosis in cancer cells. J Biol Chem. 2005 Dec 2;280(48):40084-96. Epub 2005 Sep 13.

 

Das KC, Dashnamoorthy R. (2004)
Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.

 

Ravi D, Ramadas K, Mathew BS, Panikkar KR, Nair MK, Pillai MR. (2001)
Apoptosis, angiogenesis and proliferation: trifunctional measure of tumour response to radiotherapy for oral cancer. Oral Oncol. 2001 Feb;37(2):164-71.