Cellular and Structural Biology | Faculty
Department of Cellular & Structural Biology

CSB Faculty

 

Photo of Dr. Bandyopadhyay Abhik Bandyopadhyay, Ph.D.
Assistant Professor/Research

 

University of Calcutta, India, 1986

 

MED 2.009V
210-567-0849
bandyopadhy@uthscsa.edu

 

I joined CSB in Dr. LuZhe Sun's laboratory as a research faculty in 2001. I obtained my Ph.D. degree in Biochemistry from Calcutta University on my studies in diabetes mellitus and hyperlipidemia at the Vivekananda Institute of Medical Sciences, Calcutta. My post-doctoral experience includes 1) cellular and molecular characterization of carcinogen induced mammary carcinoma utilizing mouse mammary gland organ culture model system at the Tumor Biology Laboratory in University of Nebraska, Lincoln, 2) drug induced Cytochrome P450 gene expression and regulation studies in tissue culture and rodent models and molecular mechanism of active drug transport into the mammary gland in rodent models at the department of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Kentucky at Lexington and 4) evaluating the role of transforming growth factor beta in cancer in in vitro and animal models in the department of Pharmacology of the University of Kentucky at Lexington.

 

My current research focusses on breast cancer prevention, early diagnosis and curative treatment. The current treatment of chemotherapy and radiation can effectively target the primary breast tumors but often fail to prevent or cure recurrence. Better insight into the cellular and molecular biology of breast cancer initiation and progression to metastasis is highly needed for both prevention and effective treatment.

 

Recent scientific evidence indicates that stem cells provide powerful models of the cellular and molecular origins of many cancer types. Recent identification of stem like self renewing and drug resistant cancer cells as the progenitors of breast tumors raise the exciting prospect that effective targeting of these cells could prevent breast tumor recurrence following initial treatment. But the origin and how breast cancer stem cells drive the multistage cancer progression is still unknown.

Dr. Bandyopadhyay - Regeneration of murine mammary gland

 

My research interest includes:

  1. Cellular and molecular mechanism of neoplastic transformation of mammary stem cells in murine and human breast.
  2. Targeting cancer stem cell initiation and progression pathways by molecular therapeutic agents in pre-clinical animal models.
Dr. Bandyopadhyay - GFP Sphere

 

Breast cancer is also considered as a heterogeneous age-associated malignancy. About 80% of all breast cancers arise in women over age 50. My research interest is also to elucidate the role of mammary stem/progenitor cell function and genomic integrity in relation to the development of age-associated breast cancer in a murine model of aging.

 

 

Research Techniques:

  • Murine models of human cancer for pre-clinical studies of tumor growth, angiogenesis and metastasis (Lung, brain and bone)
  • Isolation and functional characterization of mammary stem cells by flow-cytometry, mammosphere culture, time-lapse imaging and regeneration of mammary glands by mammary fat pad transplantation
  • Primary, immortal and tumor cell culture for carcinogenesis, morphogenesis, gene expression, DNA repair and Elisa studies
  • Immunohistochemistry and immuno-fluorescence staining

 

PUBLICATIONS:
Bandyopadhyay A, Wang L, Agyin J, Tang Y, Lin S, Yeh IT, De K, Sun LZ. (2010) Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PLoS One. 2010 Apr 28;5(4):e10365.

 

Bandyopadhyay A, Wang L, Chin SH, Sun LZ. (2007) Inhibition of skeletal metastasis by ectopic ERalpha expression in ERalpha-negative human breast cancer cell lines. Neoplasia. 2007 Feb;9(2):113-8.

 

Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun LZ. (2006) Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res. 2006 Jul 1;66(13):6714-21.

 

Bandyopadhyay A, Lopez-Casillas F, Malik SN, Montiel JL, Mendoza V, Yang J, Sun LZ. (2002) Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res. 2002 Aug 15;62(16):4690-5.

 

Bandyopadhyay A, Cibull ML, Sun LZ. (1998) Isolation and characterization of a spontaneously transformed malignant mouse mammary epithelial cell line in culture. Carcinogenesis. 1998 Nov;19(11):1907-11.

 

Bandyopadhyay AM, Chaudhary I, Robertson LW, Gemzik B, Parkinson A, Blouin RA. (1993) Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment. Arch Biochem Biophys. 1993 Dec;307(2):386-90.