Thomas S. King, Ph.D.Associate Professor
Medical University of South Carolina, 1980
Dr. King is course director for Medical Microscopic Anatomy, lecturer in Medical Neuroscience and lecturer in Medical Pathology. Dr. King also participates as an instructor in the review course for the USMLE, Step I for second year medical students. He also has a faculty appointment in the Department of Obstetrics and Gynecology where he directs the Neuroendocrine Research Laboratory. As a member of the Division of Reproductive Endocrinology and Infertility (OB-GYN), Dr. King actively participates in the clinical fellows training program. He has been actively involved in development of the new integrated medical curriculum for first and second year students as a member of the Medical Curriculum Committee. Dr. King is also a member of the Selection Subcommittee of the Medical Admissions Committee.
Dr. King's research is a component of a larger, interdepartmental collaboration with a primary focus on the regulation of hypothalamic GnRH secretion. Several years ago, his collaborative group began to examine an immortalized neuronal cell line (GT1-7) which secretes GnRH in pulses in a manner similar to pulsatile secretion of GnRH from the rat hypothalamus in vitro and the hypothalamus of ovariectomized rats in situ. Secretion of GnRH from these cells can be stimulated by numerous secretogogues including GABAA receptor agonists such as muscimol. GABAergic mechanisms regulating GnRH secretion from these cells is of particular interest since various chemical substances are know to alter reproductive function via activity at these receptor complexes.
Dr. King is also an active participant in an interdepartmental research group focusing on neural plasticity in the CNS regulation of blood pressure. He is currently involved in studies related to hypothalamic glutamate uptake and release. The group is also involved in studies to define the actions of CRH and glucocorticoids (e.g., cortisol or corticosterone) to modulate such neural plasticity in relation to chronic stress.
M.A. Javors, P. Bean, T.S. King, and R.F.Anton: Biochemical Markers for Alcohol Consumption. In: Handbook of Clinical Alcoholism Treatment (B.A. Johnson, P. Ruiz and M. Galanter, eds.) Baltimore: Lippincott Williams and Wilkins, pp. 62 - 79, 2003.
Chen, E.C., M.A. Javors, C. Norris, T. Siler-Khodr, R.S. Schenken and T.S. King: Dependence of cyclic AMP stimulated GnRH release on intracellular calcium levels and L-type calcium channels in superfused GT1-7 neurons. J. Soc. Gynecol. Invest., in press, 2004.
King, T.S., M. McNichols, M.S. Canez, M.A. Javors and R.S. Schenken: Effect of acute cocaine administration on pituitary gonadotropin secretion in the female rat. Reproduction 122: 723 - 729, 2001.
Javors, M.A., J. Sanchez, T.S. King and C.M. Flores: Extraction and quantification of epibatidine in plasma. J. Chromatogr. B755: 379 - 382,2001.
King, T.S., D. Potter, I.S. Kang, C. Norris, E. Chen, R.S. Schenken, and M.A. Javors. (1999) Concentration dependent effect of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro. Brain Res. 824:56-62.