Genetics, Genomics
& Development Resources

Faculty List (pdf)
Track Handbook (doc)

Department of
Cellular and Structural Biology

Genetics, Genomics & Development Track

 

The Genetics, Genomics & Development Track embraces three complementary disciplines to provide students with a solid foundation of training that will prepare them for careers in some of the most exciting areas of modern biomedical research.

 

Research and training opportunities within the program include molecular genetics of human disease, genetics of complex disorders, use of genetic animal models, genomics, proteomics, stem cell biology and reproductive and developmental biology.

 

Elective courses in specialized areas of the track are available including Medical Genetics , Developmental and Stem Cell Biology, Genomics and Proteomics, and Animal Models.

 

Additional electives are available through other graduate school tracks to allow the student to fully enjoy and benefit from multidisciplinary training.

 

Genetics, Genomics & Development - CSB Faculty:

 

Genetics, Genomics & Development Track Complete Faculty List and Interests:

 

Sunil Ahuja, Medicine/Infectious Diseases - Understanding the role of the chemokine system and other immune molecules in HIV-1 pathogenesis.

 

Timothy J. Anderson, Genetics, TBRI - Genetics, genomics and evolution of malaria and schistosome parasites of humans.

 

Nedal Arar, Medicine/Nephrology - Renal Disease.

 

Yidong Bai, Cellular & Structural Biology - Mitochondrial, respiratory chain, complex assembly, turnover, copy number control.

 

Manzoor A. Bhat, - Genetic and Molecular Dissection of Neuron-Glial Interactions in Drosophila and Mice.

 

Alex Bishop, Cellular & Structural Biology - Understanding the contribution of different genes to genomic instability and the role of such instability in development, aging and carcinogenesis.

 

Thomas Boyer, Molecular Medicine - Biochemical, molecular, and cell biological approaches to study the regulation of eukaryotic RNA polymerase II transcription.

 

Melanie A. Carless, - Our research focuses on identifying epigenetic variation that contributes to the development of various complex diseases and how these changes might influence and interact with genetic variation to propel disease progression.

 

Yidong Chen, Epidemiology and Biostatistics - Bioinformatics, statistical, and systems biology methods for modeling tumor phenotype, genotype and compound treatment responses.

 

Jannine Cody, Pediatrics - Understanding the molecular basis, clinical and educational features as well as the natural history of individuals with syndromes of chromosome 18.

 

Joanne E. Curran, Genetics, TBRI - Our research focuses on dissecting diseases such as type 2 diabetes, obesity and cardiovascular disease in the general population, to gain an insight into the biological pathways involved in disease pathogenesis.

 

Patricia Dahia, Medicine / Hematology - Utilization of genomics-based approaches to study the genetics of cancer, to characterize interactions between oncogenic pathways, and to identify novel cancer-related genes.

 

Stephen E. Harris, Periodontics - Bone Morphogenetic Protein and their Expression.

 

Samy L. Habib, Cellular & Structural Biology - Research focuses on the molecular mechanisms mediating fibrosis, hypertrophy and apoptosis in diabetic nephropathy, and defining the role of diabetes in the development of renal tumors.

 

Lorena M. Havill, Genetics, TBRI - We investigate variation in risk of two common aging-related diseases of the skeletal system: Osteoporosis ("fragile bone disease") and osteoarthritis. These disorders are extremely common age-related skeletal diseases, but their causes and the ability to prevent and treat them remain elusive.

 

Tim Hui-Ming Huang, - He studies cancer epigenetics. He has pioneered the development of high-throughput technologies that are used to investigate molecular interactions between DNA methylation and histone modifications during tumorigenesis.

 

Syed Z. Imam, Medicine / Inf. Diseases - Understanding the molecular basis of neurodegeneration, which can be implicated to develop therapeutic trials for neurodegenerative diseases.

 

Teresa Johnson-Pais, Pediatrics - Identification of genetic alterations that play a role in cancer tumorigenesis, especially in urologic cancers. Genetics of Paget's Disease of Bone - Understanding the role of mutant SQSTM1 proteins in familial Paget's Disease of Bone.

 

David Kadosh, Microbiology / Immunology - Regulation of morphology and virulence in the major human fungal pathogen Candida albicans.

 

Erzsebet K. Kokovay, Cellular & Structural Biology - Cellular and molecular mechanisms of neural stem cell regulation, especially those derived from the microenvironment.

 

Ellen B. Kraig, Cellular & Structural Biology - Effects of aging and infection on immunity and autoimmunity.

 

Pamela Larsen, Cellular & Structural Biology - Understanding the biological mechanisms for the efficient life maintenance, in development and adulthood in C. elegans.

 

Robin Leach, Cellular & Structural Biology - Using a molecular genetic approach, we are studying a number of common diseases including prostate and testicular cancer, diabetes, schizophrenia and Paget's disease of the bone.

 

Sang Lee, Molecular Medicine - Cancer results from genetic and environmental insults leading to the accumulation of mutations in genes preventing the initiation and the progression of this disease.

 

Donna Lehman, Medicine / Epidemiology - Public health genomics; study of genetics of complex disorders such as diabetes using genetic epidemiologic methods in large family-based and population-based cohorts; Genetic cause of various highly penetrant ophthalmic disorders.

 

Philip LoVerde, Biochemistry / Pathology - Elucidating molecular mechanisms of schistosome-host interactions by investigating the role of genes and gene products such as those contributing to female reproductive development and those encoding antigens.

 

John McCarrey, Cellular & Structural Biology - Mechanisms regulating the development, differentiation and manipulation of germ cells and stem cells in mammals.

 

Charleen Moore, Cellular & Structural Biology - Characterizing human cytogenetic abnormalities and carrying out comparative cytogenetics studies in primates and marsupials.

 

Leslie Myatt, Obstetrics and Gynecology - My lab studies a). the role of the placenta in the developmental origins of health and disease (fetal programming) with a particular focus on the effect of maternal obesity on generation of inflammation and oxidative/nitrative stress and on mitochondrial function in the placenta and b). epigenetic regulation of gene expression in the placenta and in the myometrium.

 

Susan S. Padalecki, Urology / Cellular & Structural Biology - Bone is the most common site of metastases for solid tumors such as breast, prostate and bladder cancers. These metastases contribute significantly to the morbidity and mortality of these cancers.

 

Dubravko Pavlin, Orthodontics - Regulation of genes for bone cell (osteoblast) markers.

 

Luiz Penalva, Cellular & Structural Biology - Dissecting gene expression of tumors and complex tissues with RNA binding proteins.

 

Alexander Pertsemlidis, Pediatrics and Greehey Children's Cancer Research Institute - microRNA regulation of cell viability and drug response in cancer.

 

Ravi Ranjan, Pharmacology - The genetics of aging in Drosophila and the mechanism of neurotransmitter secretion at the synapse.

 

Shane L. Rea, Barshop / Physiology - Aging in C. elegans (Mit Mutants; Mitochondrial; Bioenergetics; Metabolomics; DNA Damage); Human Mitochondrial-associated Disorders (S. cerevisiae Models); Type II Diabetes.

 

Vivienne Rebel, Cellular & Structural Biology - We are interested in understanding how blood-forming stem cells are regulated and how these regulatory processes are affected by disease (such as myelodysplastic syndrome and leukemia) and age. In our studies we use mouse models and we study both stem cell intrinsic - and extrinsic (microenvironment-mediated) regulatory mechanisms.

 

Paula Shireman, Surgery - Our lab studies the inflammatory-mediated mechanisms of angiogenesis and skeletal muscle regeneration. We are particularly interested in how hematopoietic stem cells, myogenic stem cells and inflammatory cells interact to form muscle after injury and microRNA regulation of this process. A better understanding of muscle regeneration will be useful in tissue regeneration strategies for limb salvage.

 

Thomas Slaga, Pharmacology - Glucocorticoid hormones (GC), very potent inhibitors of physiological DNA synthesis in keratinocytes in vivo.

 

Brent J. Thompson, Cellular & Structural Biology - Understanding of how SSRI class antidepressants, such as Prozac, exert their clinical effect and Influence of maternal nutrition on fetal brain development.

 

Gail Tomlinson, Pediatrics - Genetic predisposition to cancer, Hepatoblastoma, Hereditary breast cancer, Other Pediatric Tumors, Population-specific aspects of childhood cancer, von Hippel-Lindau disease.

 

Kristine S. Vogel, Cellular & Structural Biology - Neurofibromatosis Type 1 and Genomic Instability.

 

M. Consuelo Walss-Bass, Psychiatry - Role of genetic polymorphisms in risk of Schizophrenia and Bipolar Disorder.

 

Christi Walter, Cellular and Structural Biology - DNA repair, mutagenesis, mitochondria, transgenic mice, aging, spermatogenic cells.

 

Degeng Wang, Epidemiology and Biostatistics - His lab focuses on understanding the operations of cellular biochemical networks and their aberrancy in cancers, with a current emphasis on cancer metabolism.

 

Pei Wang, Cellular & Structural Biology - Her research goals are to identify markers and methods for early diagnosis of Pancreatic ductal adenocarcinoma and to inform the development of effective therapeutic strategies.

 

P. Renee Yew, Molecular Medicine - Vertebrate cell cycle regulation, DNA replication initiation, Ubiquitin-mediated proteolysis and signaling, Tumor suppressor function.