Russel J. Reiter, Ph.D.Professor
Bowman Gray School of Medicine, 1964
Besides investigating the functional relevance of free radicals to age-associated organ deterioration, Dr. Reiter's group is investigating the free radical scavenging and antioxidant properties of pineal indoleamines, most notably melatonin. The investigations include the mechanisms of interaction of melatonin with free radicals and the resulting products. These studies have utilized thermodynamic analyses, electron ionization mass spectroscopy, nuclear magnetic resonance, high performance liquid chromotography, electron spin resonance spectroscopy and biochemical and molecular biological techniques to unravel the processes involved. This research group is also investigating the role of melatonin as a antitoxin against a variety of xenobiotics and environmental pollutants and the functional significance of melatonin and other indoleamines with processes of aging.
El-Sokkary, G.H., Omar, H.M., Hassanien, A.F.M.M., Cuzzocrea, S., Reiter, R.J. (2002) Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free Radical Biol. Med., 32:319-332.
Reiter, R.J., Tan, D.X., Manchester, LC., Qi, W. (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell. Biochem. Biophys., 34:237-256.
Gitto, E., Karbownik, M., Reiter, R.J., Tan, D.X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G., Barberi, I. (2001) Effects of melatonin in septic newborns. Pediatr. Res., 50:756-760.