Arunabh Bhattacharya, Ph.D.Assistant Professor/Research
Jadavpur University, India, 2001
Recent studies in older humans suggest a strong association between decline in peripheral motor nerve function and decrease in muscle power. Structural changes in peripheral nerves during aging include the loss of axons and demyelination. Myelin sheath produced by Schwann cells that surround the large myelinated nerve fibers is highly enriched in both lipids and proteins, making it highly susceptible to oxidative damage. Using longitudinal measures of peripheral motor nerve and muscle function, the laboratory is investigating if rescuing oxidative damage mediated degenerative changes in peripheral nerves from aging mice protects peripheral nerve dysfunction and the loss of skeletal muscle mass and function.
Finally, pilot studies are underway in the laboratory to investigate the role of mitochondrial oxidative stress and oxidative damage in Traumatic Brain Injury. This project is in collaboration with Dr. Lora Talley Watts, Assistant Professor/Research, Department of Cell Systems & Anatomy, UTHSCSA.
(A) Respresentative chromatograms of 5- and 12-HETE in sciatic nerves from young (8 mo) and old (30 mo) C57BL/6 mice that were analyzed by LC-MS/MS.
(B) Quantification of 5-LO, 12/15-LO and COX pathway derived oxidized fatty acids in sciatic nerves from young and old C57BL/6 mice.
Dental Gross Anatomy (CSBL 5016)
Dental Neuroscience (CSBL 5020)
Interprofessional Gross Anatomy (CSBL 5022)
Introduction to Research (CSBL 5074)
Introduction of Biomedical Science (IBMS 5000)
Bhattacharya A, Hamilton R, Jernigan A, Zhang Y, Sabia M, Rahman MM, Li Y, Wei R, Chaudhuri A, Van Remmen H. (2014) Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy. Free Radic Biol Med. 2014 Feb;67:30-40.
Pulliam DA, Bhattacharya A, Van Remmen H. (2013) Mitochondrial dysfunction in aging and longevity: a causal or protective role? Antioxid Redox Signal. 2013 Oct 20;19(12):1373-87.
Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H. (2013) Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One. 2013 Jun 4;8(6):e65725.
Bhattacharya A, Lustgarten M, Shi Y, Liu Y, Jang YC, Pulliam D, Jernigan AL, Van Remmen H. (2011) Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria. Free Radic Biol Med. 2011 Mar 1;50(5):592-601.
Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. (2012) Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct;11(5):770-82.
Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, Richardson A, Van Remmen H. (2012) Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiol Aging. 2012 Aug;33(8):1829-32.