Department of Cell Systems & Anatomy

CSA Faculty

 

Arunabh Bhattacharya, Ph.D.

Assistant Professor/Research

 

Jadavpur University, India, 2001

 

MED 240D
(210) 567-3848
Bhattacharya@uthscsa.edu

 

Dr. Bhattacharya's laboratory is interested in the biochemical and molecular mechanisms underlying sarcopenia, the age-related loss of skeletal muscle mass and function that significantly compromises the quality of life and increases the risk of morbidity and mortality in the elderly. Specifically, the laboratory is investigating the role of lipid metabolic pathways that generate oxidized fatty acids (e.g., 5- and 12/15-lipoxygenase) in inflammation and oxidative damage and its impact on sarcopenia.

 

Recent studies in older humans suggest a strong association between decline in peripheral motor nerve function and decrease in muscle power. Structural changes in peripheral nerves during aging include the loss of axons and demyelination. Myelin sheath produced by Schwann cells that surround the large myelinated nerve fibers is highly enriched in both lipids and proteins, making it highly susceptible to oxidative damage. Using longitudinal measures of peripheral motor nerve and muscle function, the laboratory is investigating if rescuing oxidative damage mediated degenerative changes in peripheral nerves from aging mice protects peripheral nerve dysfunction and the loss of skeletal muscle mass and function.

 

Finally, pilot studies are underway in the laboratory to investigate the role of mitochondrial oxidative stress and oxidative damage in Traumatic Brain Injury. This project is in collaboration with Dr. Lora Talley Watts, Assistant Professor/Research, Department of Cell Systems & Anatomy, UTHSCSA.
(A) Respresentative chromatograms of 5- and 12-HETE in sciatic nerves from young (8 mo) and old (30 mo) C57BL/6 mice that were analyzed by LC-MS/MS.
(B) Quantification of 5-LO, 12/15-LO and COX pathway derived oxidized fatty acids in sciatic nerves from young and old C57BL/6 mice.

    Dental Gross Anatomy (CSBL 5016)
    Dental Neuroscience (CSBL 5020)
    Interprofessional Gross Anatomy (CSBL 5022)
    Introduction to Research (CSBL 5074)
    Introduction of Biomedical Science (IBMS 5000)
Recent Publications:
Bhattacharya A, Wei R, Hamilton RT, Chaudhuri AR. (2014) Neuronal cells but not muscle cells are resistant to oxidative stress mediated protein misfolding and cell death: role of molecular chaperones. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1250-4.

 

Bhattacharya A, Hamilton R, Jernigan A, Zhang Y, Sabia M, Rahman MM, Li Y, Wei R, Chaudhuri A, Van Remmen H. (2014) Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy. Free Radic Biol Med. 2014 Feb;67:30-40.

 

Pulliam DA, Bhattacharya A, Van Remmen H. (2013) Mitochondrial dysfunction in aging and longevity: a causal or protective role? Antioxid Redox Signal. 2013 Oct 20;19(12):1373-87.

 

Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H. (2013) Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One. 2013 Jun 4;8(6):e65725.

 

Bhattacharya A, Lustgarten M, Shi Y, Liu Y, Jang YC, Pulliam D, Jernigan AL, Van Remmen H. (2011) Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria. Free Radic Biol Med. 2011 Mar 1;50(5):592-601.

 

Representative Publications:
Walsh ME, Bhattacharya A, Liu Y, Van Remmen H. (2015) Butyrate prevents muscle atrophy after sciatic nerve crush. Muscle Nerve. 2015 Feb 27.

 

Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. (2012) Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct;11(5):770-82.

 

Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, Richardson A, Van Remmen H. (2012) Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiol Aging. 2012 Aug;33(8):1829-32.