Department of Cell Systems & Anatomy

CSA Faculty

 

Yidong Bai, Ph.D.

Associate Professor

 

Columbia University, 1996

 

MED 221D
(210) 567-0561
Baiy@uthscsa.edu

 

We are interested in a comprehensive understanding of mitochondrial function at the molecular, cellular, tissue, and animal levels. Mitochondria play a central role in cellular energy and also regulate apoptosis, signal transduction and cell growth. Mitochondrial defects have been reported in a wide range of conditions, such as diabetes, neurodegenerative diseases, cancers, and aging. The central theme in the laboratory is to investigate the regulatory mechanisms working in mitochondria and the role of mitochondria in regulating various cellular pathways. In particular, we are interested in the dynamics of the machinery for oxidative phosphorylation, the role of mitochondrial dysfunction in human diseases including cancer and aging process. various approaches are also explored in restoring the mitochondrial function in cells with mitochondrial deficiency.

 

 

Dr. Bai is the current COGS chair of CSA master program.

 

Course Director:
    Mitochondria and Apoptosis (INTD 6008)
    Introduction to Research (CSBL 5074)
Instructor:
    Obesity Module of Fundamentals of Biomedical Sciences (INTD 5000)
    Biology of Aging (CSBL 6048)
Recent Publications:
Chen H, Bai J, Dong F, Fang H, Zhang Y, Meng W, Liu B, Luo Y, Liu M, Bai Y, Abdul-Ghani MA, Li R, Wu J, Zeng R, Zhou Z, Dong LQ, Liu F. Hepatic DsbA-L protects mice from diet-induced hepatosteatosis and insulin resistance. FASEB J. 2017 Jun;31(6):2314-2326.

 

Li H, Shen L, Hu P, Huang R, Cao Y, Deng J, Yuan W, Liu D, Yang J, Gu H, Bai Y. Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions. Biochim Biophys Acta. 2017 May 27.

 

Etzler JC, Bollo M, Holstein D, Deng JJ, Perez V, Lin DT, Richardson A, Bai Y, Lechleiter JD. Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation. Arch Biochem Biophys. 2017 Jan 1;613:61-68.

 

Mishur RJ, Khan M, Munkácsy E, Sharma L, Bokov A, Beam H, Radetskaya O, Borror M, Lane R, Bai Y, Rea SL. Mitochondrial metabolites extend lifespan. Aging Cell. 2016 Apr;15(2):336-48.

 

Nie H, Chen G, He J, Zhang F, Li M, Wang Q, Zhou H, Lyu J, Bai Y. Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress. Mitochondrion. 2016 Jan;26:104-12.

 

Representative Publications:
Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation.Hum Mol Genet. 2011 Dec 1;20(23):4605-16.

 

Li Y, Li HZ, Hu P, Deng J, Banoei MM, Sharma LK, Bai Y. Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging. Nucleic Acids Res. 2010 Apr;38(6):1913-21.

 

Park JS, Sharma LK, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J, Bai Y. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009 May 1;18(9):1578-89.

 

Li Y, D'Aurelio M, Deng JH, Park JS, Manfredi G, Hu P, Lu J, Bai Y. An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria.J Biol Chem. 2007 Jun 15;282(24):17557-62.

 

Deng JH, Li Y, Park JS, Wu J, Hu P, Lechleiter J, Bai Y. Nuclear suppression of mitochondrial defects in cells without the ND6 subunit. Mol Cell Biol. 2006 Feb;26(3):1077-86.

 

Faculty members:
    Janice Deng, MD. - Instructor with MD from Xian Jiaotong University
Graduate students:
    Yusheng Qian - MS student on Biotech track with BA from University of Arizona
    Pragya Singh - MS student on Biotech track with BA from University of Arkansas
Visiting students:
    Chaoying Qin - Visiting MD student, Xiangya Medical School, China
    Leonardo Menezes - Visiting PhD student, São Paulo State University, Brazil
    Min Zhu - Visiting Scientist, Xiangya Medical School, China
Summer students:
    Xavier Tijerina - St Mary University
    Deanna Smith - Voelcker Academy
    Kevin Alvarez - Voelcker Academy