Edward G. Rennels Distinguished Lecture Series
Marc Diamond, M.D.
Director, Center for Alzheimer's and Neurodegenerative Diseases
UT Southwestern Medical Center
"Tau Prions: Insights into initiation and diversity of neurodegenerative diseases"
Seminal work from Dr. Diamond's laboratory revealed that tau, a key pathological player in many neurodegenerative diseases, adopts prion-like characteristics that help explain its pathological spread through the human brain. The primary focus of Dr. Diamond's work is to understand how amyloid-forming proteins propagate a misfolded state between cells. Recent breakthroughs include the invention of a cell-based platform for detecting minute levels of amyloid seeds in biospecimens, and an immunotherapy-based approach that improves cognition in vivo. Dr. Diamond earned his MD from the University of California San Francisco and was the David Clayson Professor of Neurology at Washington University in St. Louis prior to his recruitment to UTSW.
In 1966, the University of Texas opened a new medical school in San Antonio, Texas. Edward G. Rennels was selected as the founding Chair of the nascent Department of Anatomy. Over the next 14 years, he recruited faculty who shared his vision to build a department committed to excellence in scholarly achievement, graduate education and teaching. In 1980, he resigned as Chair and in 1982, was named Professor Emeritus upon retiring from the University.
The Edward G. Rennels Distinguished Lecture Series was established in 2011 in honor of our Founding Chair, Edward G. Rennels.
Tribute to Edward G. Rennels
provided by Erle K. Adrian, Damon C. Herbert, and Vick F. Williams.
Thomas Carmichael, M.D., Ph.D.
Department of Neurology,
Brain Research Institute, UCLA
"Neural Repair after Stroke"
Dr. Tom Carmichael is Professor and Co-director of the UCLA Broad Stem Cell Center and a leader in the study of the cellular and molecular mechanisms of neural repair following stroke. His work focuses on using endogenous or transplanted neural stem cells to promote remyelination and neuronal integration after stroke. Seminal findings include the identification of a neurovascular niche for neurogenesis, the role of neurotransmitters in the repair processes and how the aging brain responds to stroke. He has over 70 publications and book chapters and is currently the Associate Editor for Neurorehabilitation and Neural Repair. His many honors include a Larry L. Holblom Foundation Distinguished Scholar and the recipient of the American Society of Neurorehabilitation Outstanding Clinician-Scientist Award. He is also the Director of the largest multi-site neural repair collaboration, the Adelson Program in Neurorehabilitation and Neural Repair. Dr. Carmichael received his PhD and MD from Washington University in St. Louis, Missouri, was Chief Resident of Neurology at Washington University, School of Medicine and an HHMI Post-Doctoral Fellow at the UCLA School of Medicine.
Dr. Sally Temple
Neural Stem Cell Institute
Rensselaer, New York
"Age-related Changes in the Neural Stem Cell Niche"
Dr. Temple Co-founded the Neural Stem Cell Institute in 2007, where she serves as the Scientific Director and leads a team of 30 scientists focused on using neural stem cells to develop effective clinical treatments for CNS damage from trauma, malignancy, stroke or neurodegenerative diseases. She previously discovered that the embryonic brain contained a rare stem-like cell, which led her to make pioneering discoveries on the mechanisms as to how neural stem cells alter their development over time to generate diverse progeny. Presently, her work is funded by multiple grants from NINDS, NIA and NEI as well as the Ellison Foundation where she has received the Senior Scholar Award. Dr. Temple has authored or co-authored over 70 articles in very prestigious journals and written 10 book chapters. She is on the Editorial Boards of Neuron, Developmental Cell, Cell Stem Cell and PLOS Biology, and serves on the Medical Advisory Board of the New York Stem Cell Foundation, Medical and Scientific Advisory Board of the Genetics Policy Institute, and Board of Directors of the International Society for Stem Cell Research. Dr. Temple has received many prestigious honors and awards including the Jacob Javitz Merit Award from the NIH and a MacArthur Award in recognition of her contributions to neural stem cell developmental biology. A native of York, England, Dr. Temple received her undergraduate training at Cambridge University, her Ph.D. at the University College in London and then moved to New York to complete a postdoctoral fellowship at Columbia University. Thereafter, she became a faculty member at the University of Miami before transferring to Albany Medical School where she is currently Professor of Neuropharmacology and Neuroscience. Additionally, Dr. Temple has a faculty position as Professor in the Department of Biomedical Sciences at SUNY Albany.
Dr. Lynda F. Bonewald
Lefkowitz Professor of Oral Biology
Director of the Bone Biology Research Program
Vice Chancellor for Translational and Clinical Research
University of Missouri at Kansas City School of Dentistry
"Osteocytes -- Why we only look where the light is shining"
Lynda received her Ph.D. in Immunology/Microbiology at the University of South Carolina in 1984, after which she remained on the campus for an additional two years to pursue her postdoctoral work. She subsequently moved to UTHSCSA as an Assistant Professor in the Departments of Medicine and Cell Systems & Anatomy. She rose through the ranks to Professor in the Departments of Medicine, Cell Systems & Anatomy, and Biochemistry. While at UTHSCSA, she affiliated and collaborated with Dr. Gregory Mundy's group. In 2001, Lynda relocated to the School of Dentistry at the University of Missouri at Kansas City (UMKC) where she is the Lefkowitz Professor of Oral Biology, and Director of the Bone Biology Research Program, and of the Center of Excellence in the Study of Dental and Musculoskeletal Tissues. Additionally, she serves as the Vice Chancellor for Translational and Clinical Research at UMKC. In 2012, Lynda was elected president of the American Society for Bone and Mineral Research. She has had a long and distinguished career studying the biology of bone, bone repair and the interactions between bone and muscle. She has authored or co-authored 155 journal articles in very prestigious journals, contributed to and/or written 37 book chapters and holds 8 patents. Lynda has served on numerous NIH committees and study sections, and is currently a member of the NIH NIAMS Council. She is an Associate Editor for the Journal for Bone and Mineral Research and Experimental Biology and Medicine. Her honors are many including the Distinguished Scientist Award in Mineralized Tissue from the AADR/IADR and the Remodeling Bone Award from the Sun Valley Workshop. She has trained many high school and college students, graduate and dental students, and postdoctoral and visiting fellows. Lynda has had continuous funding throughout her academic career and currently has grants from the Department of Defense and the NIH, including a program project grant entitled "Osteocyte Regulation of Bone/Muscle with Age".
Dr. Donald J. Tindall
Professor, Director & Vice Chair of Urologic Research
Carl Rosen Professorship in Urology Mayo Clinic of Medicine
"Mechanisms of Androgen Interaction in Prostate Cancer Regression"
Donald Tindall received his Master's degree in biochemistry from Clemson University in 1970 and his doctorate also in biochemistry from the University of North Carolina in 1973. He then entered his postdoctoral work at Baylor College of Medicine in Houston. After two years, he joined the Department of Cell Biology at Baylor and rose through the ranks to Associate Professor. In 1988, he relocated to Mayo Clinic in Rochester Minnesota where he is Professor, Director and Vice Chair of Urologic Research and holds the Carl Rosen Professorship in Urology. Additionally, he is also Professor in the Department of Biochemistry and Molecular Biology at the Mayo. Don has had a long and distinguished career in male reproductive biology, androgen interactions in prostatic physiology and prostate cancer. He has authored or co-authored over 200 journal articles in very prestigious journals, contributed to and/or written more than 35 book chapters and monographs and holds 12 patents and copyrights. Don has served on various editorial boards including Co-editor-in-Chief for 13 years for the Journal of Andrology, numerous grant review panels such as NCI's SubCommittee C which reviews proposals in from both the basic and preclinical sciences and Chair of 12 site visit teams for NCI. His honors are many and include the Meritorious Achievement Award from the Society for Basic Urological Research, an NIH Career Development Award, election as President of the Society for Basic Urological Research and member of the ACR /State Legislative Committee. Don has had continuous funding from the NIH since 1976 and currently has 4 grants from NCI to fund his research endeavors studying the mechanism of androgen action prostate cancer.
Dr. Andrzej Bartke
Professor & Director of Geriatric Medicine
Southern Illinois School of Medicine
"Long and Healthy Life without Growth Hormone: Lessons from Dwarf Mice"
Andrzej Bartke received the equivalent of a Master's degree from the Jagiellonian University in Krakow, Poland in zoology in 1962 and his doctorate in zoology & genetics from the University of Kansas in 1965. He currently is Professor, Distinguished Scholar and Director of Geriatric Medicine in the Departments of Internal Medicine and Physiology Southern Illinois University School of Medicine, in Springfield. His previous positions included 18 years as Chair of Physiology at Southern Illinois University School of Medicine, Carbondale, Illinois; 6 years in the Department of Obstetrics at UTHSCSA and 9 years as a Scientist at The Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts. Andrzej has had a long and distinguished career in endocrinology having authored or co-authored nearly 550 journal articles, contributed to and written more than 130 book chapters and review articles, was the founding editor of the Journal of Andrology and currently serves as the Section Editor of the Journal of Gerontology and of Gerontology. Adrzrej was president of the American Society of Andrology, Society for the Study of Reproduction and the American Aging Association as well as having received numerous honors and awards including an honorary doctorate from Lodz Medical University in Poland. He has had continuous federal funding for his research endeavors since 1971 and is currently studying the genetic control of aging in mammals and the endocrine mechanisms, particularly growth hormone deficiency, responsible for the effects of longevity genes using the dwarf mouse model.